American Journal of Kidney Diseases
Volume 54, Issue 4 , Pages 610-618 , October 2009

Sodium Bicarbonate Plus Isotonic Saline Versus Saline for Prevention of Contrast-Induced Nephropathy in Patients Undergoing Coronary Angiography: A Randomized Controlled Trial

  • Ali Vasheghani-Farahani, MD

      Affiliations

    • Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
    • ,
  • Gelareh Sadigh, MD

      Affiliations

    • Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
    • ,
  • Seyed Ebrahim Kassaian, MD

      Affiliations

    • Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
    • Corresponding Author InformationAddress correspondence to Seyed Ebrahim Kassaian, MD, Tehran Heart Center, North Kargar Ave, Tehran, Iran 1411713138
    • ,
  • Seyed Mohammad Reza Khatami, MD

      Affiliations

    • Department of Nephrology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
    • ,
  • Akbar Fotouhi, MD

      Affiliations

    • Department of Epidemiology, Tehran University of Medical Sciences, Tehran, Iran
    • ,
  • Seyed Amir Hossein Razavi, MD

      Affiliations

    • Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
    • ,
  • Mohammad Ali Mansournia, MD

      Affiliations

    • Department of Epidemiology, Tehran University of Medical Sciences, Tehran, Iran
    • ,
  • Ahmad Yamini-Sharif, MD

      Affiliations

    • Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
    • ,
  • Alireza Amirzadegan, MD

      Affiliations

    • Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
    • ,
  • Mojtaba Salarifar, MD

      Affiliations

    • Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
    • ,
  • Saeed Sadeghian, MD

      Affiliations

    • Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
    • ,
  • Gholamreza Davoodi, MD

      Affiliations

    • Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
    • ,
  • Mohammad Ali Borumand, MD

      Affiliations

    • Division of Laboratory, Tehran Heart Center, Tehran, Iran
    • ,
  • Farah Aiatollahzade Esfehani, BSc, RN

      Affiliations

    • Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
    • ,
  • Sirous Darabian, MD

      Affiliations

    • Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

Received 29 January 2009 ,Accepted 13 May 2009.

References 

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  5. Schmidt P, Pank D, Nykamp D, Knowlton G, Jia H. N-Acetylcysteine and sodium bicarbonate versus N-acetylcysteine and standard hydration for the prevention of radiocontrast-induced nephropathy following coronary angiography. Ann Pharmacother. 2007;41:46–50
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  26. Brar SS, Shen AY, Jorgensen MB, et al. Sodium bicarbonate vs sodium chloride for the prevention of contrast medium-induced nephropathy in patients undergoing coronary angiography: A randomized trial. JAMA. 2008;300:1038–1046
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  28. Mehran R, Aymong ED, Nikolsky E, et al. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: Development and initial validation. J Am Coll Cardiol. 2004;44:1393–1399
  29. Mueller C, Buerkle G, Buettner HJ, et al. Prevention of contrast media-associated nephropathy: Randomized comparison of 2 hydration regimens in 1620 patients undergoing coronary angioplasty. Arch Intern Med. 2002;162:329–336
  30. Montori VM, Devereaux PJ, Adhikari NK, et al. Randomized trials stopped early for benefit. JAMA. 2005;294:2203–2209
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  32. Merten GJ, Burgess WP, Rittase RA, Kennedy TP. Prevention of contrast-induced nephropathy with sodium bicarbonate: An evidence-based protocol. Crit Pathw Cardiol. 2004;3:138–143

 Originally published online as doi: 10.1053/j.ajkd.2009.05.016 on July 21, 2009.

 Trial registration: www.ClinicalTrials.gov; study number, NCT00514150.

PII: S0272-6386(09)00861-0

doi: 10.1053/j.ajkd.2009.05.016

American Journal of Kidney Diseases
Volume 54, Issue 4 , Pages 610-618 , October 2009

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