American Journal of Kidney Diseases
Volume 54, Issue 4 , Pages 619-637 , October 2009

Benefits and Harms of Phosphate Binders in CKD: A Systematic Review of Randomized Controlled Trials

  • Sankar D. Navaneethan, MD, MPH

      Affiliations

    • Corresponding Author InformationAddress correspondence to Sankar D. Navaneethan, MD, MPH, Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Ave, Q7, Cleveland, OH 44122
    • ,
  • Suetonia C. Palmer, MBChB
    • ,
  • Jonathan C. Craig, MBChB, PhD
    • ,
  • Grahame J. Elder, PhD
    • ,
  • Giovanni F.M. Strippoli, MD, PhD, MPH, MM

      Affiliations

    • Corresponding Author InformationGiovanni F.M. Strippoli, MD, PhD, MPH, MM, Department of Pharmacology and Clinical Epidemiology, Renal Division, Mario Negri Sud Consortium, S Maria Imbaro (Ch), Italy

Received 13 February 2009 ,Accepted 5 June 2009.

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    Literature search flow diagram. Reasons for exclusions and number of trials reporting each outcome are shown.

    Literature search flow diagram. Reasons for exclusions and number of trials reporting each outcome are shown.

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    Effect of sevelamer compared with calcium salts on all-cause mortality in people with chronic kidney disease. Abbreviation: CI, confidence interval.

    Effect of sevelamer compared with calcium salts on all-cause mortality in people with chronic kidney disease. Abbreviation: CI, confidence interval.

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    Effect of phosphate binders on end-of-treatment serum phosphorus concentration in people with chronic kidney disease. Conversion factor for phosphorus in mg/dL to mmol/L, ×0.3229. Abbreviation: CI, co

    Effect of phosphate binders on end-of-treatment serum phosphorus concentration in people with chronic kidney disease. Conversion factor for phosphorus in mg/dL to mmol/L, ×0.3229. Abbreviation: CI, confidence interval.

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    Effect of phosphate binders on end-of-treatment parathyroid hormone concentration (pg/mL) in people with chronic kidney disease. Parathyroid hormone in pg/mL and ng/L requires no conversion. Abbreviat

    Effect of phosphate binders on end-of-treatment parathyroid hormone concentration (pg/mL) in people with chronic kidney disease. Parathyroid hormone in pg/mL and ng/L requires no conversion. Abbreviation: CI, confidence interval.

 Originally published online as doi:10.1053/j.ajkd.2009.06.004 on August 19, 2009.

 This review is excerpted from a Cochrane Review to be published in The Cochrane Library (http://www3.interscience.wiley.com/cgi-bin/mrwhome/106568753/HOME). Cochrane Reviews are regularly updated as new evidence emerges in response to comments and criticisms, and The Cochrane Library should be consulted for the most recent version of the review.

PII: S0272-6386(09)00865-8

doi: 10.1053/j.ajkd.2009.06.004

American Journal of Kidney Diseases
Volume 54, Issue 4 , Pages 619-637 , October 2009

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