American Journal of Kidney Diseases
Volume 54, Issue 5 , Pages 792-794 , November 2009

p-Cresol Sulfate: Further Understanding of Its Cardiovascular Disease Potential in CKD

  • James F. Winchester, MD

      Affiliations

    • Albert Einstein College of Medicine, Bronx, New York
    • Corresponding Author InformationAddress correspondence to James F. Winchester, MD, FRCP (Glas), Division of Nephrology and Hypertension, Beth Israel Medical Center, Baird Hall, 18BH26, 350 East 17th St, New York, NY 10003
    • ,
  • Thomas H. Hostetter, MD

      Affiliations

    • Albert Einstein College of Medicine, Bronx, New York
    • ,
  • Timothy W. Meyer, MD

      Affiliations

    • Stanford University Medical Center, Palo Alto, California

References 

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  2. Meijers BKI, Van kerckhoven S, Verbeke K, et al. The uremic retention solute p-cresyl sulfate and markers of endothelial damage. Am J Kidney Dis. 2009;54:891–901
  3. Meijers BK, Bammens B, De Moor B, et al. Free p-cresol is associated with cardiovascular disease in hemodialysis patients. Kidney Int. 2008;73:1174–1180
  4. Chironi GN, Boulanger CM, Simon A, et al. Endothelial microparticles in diseases. Cell Tissue Res. 2009;335:143–151
  5. Lesaffer G, De Smet R, Belpaire FM, et al. Urinary excretion of the uraemic toxin p-cresol in the rat: Contribution of glucuronidation to its metabolization. Nephrol Dial Transplant. 2003;18:1299–1306
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  8. Woods HF, Nandakumar M. Improved outcome for haemodialysis patients treated with high-flux membranes. Nephrol Dial Transplant. 2000;15(suppl 1):S36–S42
  9. Port FK, Wolfe RA, Hulbert-Shearon TE, et al. Mortality risk by hemodialyzer reuse practice and dialyzer membrane characteristics: Results from the USRDS Dialysis Morbidity and Mortality Study. Am J Kidney Dis. 2001;37:276–286
  10. Eknoyan G, Beck GJ, Cheung AK, et al. HEMO Study Group Effect of dialysis dose and membrane flux in maintenance hemodialysis. N Engl J Med. 2002;347:2010–2019
  11. Cheung AK, Rocco MV, Yan G, et al. Serum beta-2 microglobulin levels predict mortality in dialysis patients: Results of the HEMO Study. J Am Soc Nephrol. 2006;17:546–555
  12. Meijers BKI, Weber V, Bammens B, et al. Removal of the uremic retention solute p-cresol using fractionated plasma separation and adsorption. Artif Organs. 2007;32:214–219
  13. Meijers BKI, Verhamme P, Nevens F, et al. Major coagulation disturbances during fractionated plasma separation and adsorption. Am J Transplant. 2007;7:2195–2199
  14. Bammens B, Evenepoel P, Verbeke K, Vanrenterghem Y. Removal of the protein-bound solute p-cresol by convective transport: A randomized crossover study. Am J Kidney Dis. 2004;44:278–285
  15. Luo FJ, Patel KP, Marquez IO, et al. Effect of increasing dialyzer mass transfer area coefficient and dialysate flow on clearance of protein-bound solutes: A pilot crossover trial. Am J Kidney Dis. 2009 Apr 24;[Epub ahead of print]
  16. Kobayashi T, Takeda K, Ohashi A, et al. Selective removal of bisphenol A from serum using molecular imprinted polymer membranes. Ther Apher Dial. 2009;13:19–26
  17. Chang YS, Ko TH, Hsu TJ, Syu MJ. Synthesis of an imprinted hybrid organic-inorganic polymeric sol-gel matrix toward the specific binding and isotherm kinetics investigation of creatinine. Anal Chem. 2009;81:2098–2105

PII: S0272-6386(09)00929-9

doi: 10.1053/j.ajkd.2009.06.019

American Journal of Kidney Diseases
Volume 54, Issue 5 , Pages 792-794 , November 2009

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