American Journal of Kidney Diseases
Volume 54, Issue 6 , Pages 1158-1161 , December 2009

Gentamicin-Induced Bartter-like Syndrome

  • Ying-Shou Chen, MD

      Affiliations

    • Division of Nephrology, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    • Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
    • ,
  • Hua-Chang Fang, MD

      Affiliations

    • Division of Nephrology, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    • Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
    • ,
  • Kang-Ju Chou, MD

      Affiliations

    • Division of Nephrology, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    • Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
    • ,
  • Po-Tsang Lee, MD

      Affiliations

    • Division of Nephrology, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    • Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
    • ,
  • Chih-Yang Hsu, MD

      Affiliations

    • Division of Nephrology, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    • Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
    • ,
  • Wei-Cheih Huang, MD

      Affiliations

    • Division of Nephrology, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    • Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
    • ,
  • Hsiao-Min Chung, MD

      Affiliations

    • Division of Nephrology, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    • Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
    • ,
  • Chien-Liang Chen, MD

      Affiliations

    • Division of Nephrology, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    • Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
    • Corresponding Author InformationAddress correspondence to Chien-Liang Chen, MD, Division of Nephrology, Kaohsiung Veterans General Hospital, 386 Ta-Chung 1st Rd, Kaohsiung, Taiwan 813

Received 16 March 2009 ,Accepted 10 July 2009.

References 

  1. Jamison RL, Ross JC, Kempson RL, Sufit CR, Parker TE. Surreptitious diuretic ingestion and pseudo-Bartter's syndrome. Am J Med. 1982;73:142–147
  2. Shah GM, Kirschenbaum MA. Renal magnesium wasting associated with therapeutic agents. Miner Electrolyte Metab. 1991;17:58–64
  3. Ariceta G, Rodriguez-Soriano J, Vallo A, Navajas A. Acute and chronic effects of cisplatin therapy on renal magnesium homeostasis. Med Pediatr Oncol. 1997;28:35–40
  4. Lajer H, Daugaard G. Cisplatin and hypomagnesemia. Cancer Treat Rev. 1999;25:47–58
  5. Lam M, Adelstein DJ. Hypomagnesemia and renal magnesium wasting in patients treated with cisplatin. Am J Kidney Dis. 1986;8:164–169
  6. Ashraf M, Scotchel PI, Krall JM, Flink EB. Cisplatinum induced hypomagnesemia and peripheral neuropathy. Gynecol Oncol. 1983;16:309–318
  7. Chou CL, Chen YH, Chau T, Lin SH. Acquired Bartter-like syndrome associated with gentamicin administration. Am J Med Sci. 2005;329:144–149
  8. Sassen MC, Kim SW, Kwon TH, et al. Dysregulation of renal sodium transporters in gentamicin-treated rats. Kidney Int. 2006;70:1026–1037
  9. Zietse R, Zoutendijk R, Hoorn EJ. Fluid, electrolyte and acid-base disorders associated with antibiotic therapy. Nat Rev Nephrol. 2009;5:193–202
  10. Brown EM, MacLeod RJ. Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev. 2001;81:239–297
  11. Knoers NV, Starremans PG, Monnens LA. Hypokalemic tubular disorders. In:  Davison AM,  Cameron JS,  Grunfeld JP, et al. editor. Oxford Textbook of Clinical Nephrology. 3rd ed.. New York: Oxford University Press; 2005;p. 995–1004
  12. McLarnon S, Holden D, Ward D, Jones M, Elliott A, Riccardi D. Aminoglycoside antibiotics induce pH-sensitive activation of the calcium-sensing receptor. Biochem Biophys Res Commun. 2002;297:71–77
  13. el-Hajj Fuleihan G, Seifter J, Scott J, Brown EM. Calcium-regulated renal calcium handling in healthy men: relationship to sodium handling. J Clin Endocrinol Metab. 1998;83:2366–2372
  14. Wang W, Li C, Kwon TH, et al. Reduced expression of renal Na+ transporters in rats with PTH-induced hypercalcemia. Am J Physiol Renal Physiol. 2004;286:534–545

 Originally published online as doi: 10.1053/j.ajkd.2009.07.016 on September 22, 2009.

PII: S0272-6386(09)01045-2

doi: 10.1053/j.ajkd.2009.07.016

American Journal of Kidney Diseases
Volume 54, Issue 6 , Pages 1158-1161 , December 2009

Article Tools

* Image Usage & Resolution