American Journal of Kidney Diseases
Volume 54, Issue 6 , Pages 1012-1024 , December 2009

Accuracy of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Diagnosis and Prognosis in Acute Kidney Injury: A Systematic Review and Meta-analysis

  • Michael Haase, MD

      Affiliations

    • Department of Nephrology and Intensive Care Medicine, Charité University Medicine, Berlin, Germany
    • Corresponding Author InformationAddress correspondence to Michael Haase, MD, Department of Nephrology and Intensive Care Medicine, Charité-University Medicine Berlin, Campus Virchow-Klinikum, 13353 Berlin, Germany
    • ,
  • Rinaldo Bellomo, MD

      Affiliations

    • Department of Intensive Care, Austin Health, Melbourne, Australia
    • ,
  • Prasad Devarajan, MD

      Affiliations

    • Department of Pediatrics and Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
    • ,
  • Peter Schlattmann, MD, MSc

      Affiliations

    • Department of Biometry and Clinical Epidemiology, Charité University Medicine, Campus Mitte, Berlin, Germany
    • ,
  • Anja Haase-Fielitz, PharmD

      Affiliations

    • Department of Nephrology and Intensive Care Medicine, Charité University Medicine, Berlin, Germany
    • ,
  • NGAL Meta-analysis Investigator Group

Received 15 April 2009 ,Accepted 27 July 2009.

  • Image Result

    Flow of study selection. Abbreviation: NGAL, neutrophil gelatinase-associated lipocalin.

    Flow of study selection. Abbreviation: NGAL, neutrophil gelatinase-associated lipocalin.

  • Image Result

    Hierarchical summary receiver operating characteristic (HSROC) plot of neutrophil gelatinase-associated lipocalin (NGAL) to predict acute kidney injury across settings. Based on combined sensitivity (

    Hierarchical summary receiver operating characteristic (HSROC) plot of neutrophil gelatinase-associated lipocalin (NGAL) to predict acute kidney injury across settings. Based on combined sensitivity (95% confidence interval [CI]) and specificity (95% CI) weighted for sample size of each data set reflected by the size of the circles, showing average sensitivity and specificity estimate of the study results (solid square) and a 95% confidence region around it.

  • Image Result
    Hierarchical summary receiver operating characteristic (HSROC) plot of neutrophil gelatinase-associated lipocalin (NGAL) to predict the initiation of renal replacement therapy. Based on combined sensi

    Hierarchical summary receiver operating characteristic (HSROC) plot of neutrophil gelatinase-associated lipocalin (NGAL) to predict the initiation of renal replacement therapy. Based on combined sensitivity (95% confidence interval [CI]) and specificity (95% CI) weighted for sample size of each data set reflected by the size of the circles, showing average sensitivity and specificity estimate of the study results (solid square) and a 95% confidence region around it.

  • Image Result
    Hierarchical summary receiver operating characteristic (HSROC) plot of neutrophil gelatinase-associated lipocalin (NGAL) to predict in-hospital mortality. Based on combined sensitivity (95% confidence

    Hierarchical summary receiver operating characteristic (HSROC) plot of neutrophil gelatinase-associated lipocalin (NGAL) to predict in-hospital mortality. Based on combined sensitivity (95% confidence interval [CI]) and specificity (95% CI) weighted for sample size of each dataset reflected by size of circles, showing average sensitivity and specificity estimate of the study results (solid square) and a 95% confidence region around it.

 Originally published online as doi:10.1053/j.ajkd.2009.07.020 on October 22, 2009.

 Members of the NGAL Meta-analysis Investigator Group are listed at the end of this article.

PII: S0272-6386(09)01075-0

doi: 10.1053/j.ajkd.2009.07.020

American Journal of Kidney Diseases
Volume 54, Issue 6 , Pages 1012-1024 , December 2009

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