American Journal of Kidney Diseases
Volume 55, Issue 2 , Pages 269-280 , February 2010

Sleep and Fatigue Symptoms in Children and Adolescents With CKD: A Cross-sectional Analysis From the Chronic Kidney Disease in Children (CKiD) Study

  • Maria-Eleni Roumelioti, MD

      Affiliations

    • Renal-Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, PA
    • Corresponding Author InformationAddress correspondence to Maria-Eleni Roumelioti, MD, University of Pittsburgh Medical Center, Renal-Electrolyte Division, 200 Lothrop St, PUH C-1111, Pittsburgh, PA 15213
  • ,
  • Alicia Wentz, MA

      Affiliations

    • Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
  • ,
  • Michael F. Schneider, MS

      Affiliations

    • Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
  • ,
  • Arlene C. Gerson, MD, PhD

      Affiliations

    • Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD
  • ,
  • Stephen Hooper, PhD

      Affiliations

    • Department of Psychiatry and Clinical Center for the Study of Development and Learning, University of North Carolina, Chapel Hill, NC
  • ,
  • Mark Benfield, MD

      Affiliations

    • Department of Pediatrics, University of Alabama at Birmingham, School of Medicine, Birmingham, AL
  • ,
  • Bradley A. Warady, MD

      Affiliations

    • Department of Pediatrics, Children's Mercy Hospital, Kansas City, MO
  • ,
  • Susan L. Furth, MD, PhD

      Affiliations

    • Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD
  • ,
  • Mark L. Unruh, MD, MSc

      Affiliations

    • Renal-Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, PA

Received 12 May 2009 ,Accepted 14 September 2009.

References 

  1. Gerson AC, Butler R, Moxey-Mims M, et al. Neurocognitive outcomes in children with chronic kidney disease: current findings and contemporary endeavors. Ment Retard Dev Disabilities Res Rev. 2006;12(3):208–215
  2. Ward TM, Brandt P, Archbold K, et al. Polysomnography and self-reported sleep, pain, fatigue, and anxiety in children with active and inactive juvenile rheumatoid arthritis. J Pediatr Psychol. 2008;33(3):232–241
  3. Stores G. Children's sleep disorders: modern approaches, developmental effects, and children at special risk. Dev Med Child Neurol. 1999;41(8):568–573
  4. Murtagh FE, Addington-Hall J, Higginson IJ. The prevalence of symptoms in end-stage renal disease: a systematic review. Adv Chronic Kidney Dis. 2007;14(1):82–99
  5. Davis ID, Baron J, O'Riordan MA, Rosen CL. Sleep disturbances in pediatric dialysis patients. Pediatr Nephrol. 2005;20(1):69–75
  6. Applebee GA, Guillot AP, Schuman CC, Teddy S, Attarian HP. Restless legs syndrome in pediatric patients with chronic kidney disease. Pediatr Nephrol. 2009;24(3):545–548
  7. Furth SL, Cole SR, Moxey-Mims M, et al. Design and methods of the Chronic Kidney Disease in Children (CKiD) prospective cohort study. Clin J Am Soc Nephrol. 2006;1(5):1006–1015
  8. Fadrowski J, Cole SR, Hwang W, et al. Changes in physical and psychosocial functioning among adolescents with chronic kidney disease. Pediatr Nephrol. 2006;21(3):394–399
  9. Slickers J, Duquette P, Hooper S, Gipson D. Clinical predictors of neurocognitive deficits in children with chronic kidney disease. Pediatr Nephrol. 2007;22(4):565–572
  10. Gipson DS, Wetherington CE, Duquette PJ, Hooper SR. The nervous system and chronic kidney disease in children. Pediatr Nephrol. 2004;19(8):832–839
  11. Lawry KW, Brouhard BH, Cunningham RJ. Cognitive functioning and school performance in children with renal failure. Pediatr Nephrol. 1994;8(3):326–329
  12. Crittenden MR, Holliday MA, Piel CF, Potter DE. Intellectual development of children with renal insufficiency and end stage disease. Int J Pediatr Nephrol. 1985;6(4):275–280
  13. Garralda ME, Jameson RA, Reynolds JM, Postlethwaite RJ. Psychiatric adjustment in children with chronic renal failure. J Child Psychol Psychiatry. 1988;29(1):79–90
  14. Schwartz GJ, Haycock GB, Edelmann CM, Spitzer A. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics. 1976;58(2):259–263
  15. Schwartz GJ, Furth S, Cole SR, Warady B, Munoz A. Glomerular filtration rate via plasma iohexol disappearance: pilot study for chronic kidney disease in children. Kidney Int. 2006;69(11):2070–2077
  16. Schwartz GJ, Munoz A, Schneider MF, et al. New equations to estimate GFR in children with CKD. J Am Soc Nephrol. 2009;20(3):629–637
  17. Varni JW, Burwinkle TM, Seid M, Skarr D. The PedsQL 4.0 as a pediatric population health measure: feasibility, reliability, and validity. Ambul Pediatr. 2003;3(6):329–341
  18. Varni JW, Seid M, Kurtin PS. PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory Version 4.0 Generic Core Scales in healthy and patient populations. Med Care. 2001;39(8):800–812
  19. Feldman HI, Appel LJ, Chertow GM, et al. The Chronic Renal Insufficiency Cohort (CRIC) Study: design and methods. J Am Soc Nephrol. 2003;14(7 suppl 2):S148–S153
  20. Back SE, Krutzen E, Nilsson-Ehle P. Contrast media as markers for glomerular filtration: a pharmacokinetic comparison of four agents. Scand J Clin Lab Invest. 1988;48(3):247–253
  21. Gaspari F, Perico N, Ruggenenti P, et al. Plasma clearance of nonradioactive iohexol as a measure of glomerular filtration rate. J Am Soc Nephrol. 1995;6(2):257–263
  22. Olsson B, Aulie A, Sveen K, Andrew E. Human pharmacokinetics of iohexol (A new nonionic contrast medium). Invest Radiol. 1983;18(2):177–182
  23. Krutzen E, Back SE, Nilsson-Ehle I, Nilsson-Ehle P. Plasma clearance of a new contrast agent, iohexol: a method for the assessment of glomerular filtration rate. J Lab Clin Med. 1984;104(6):955–961
  24. Nilsson-Ehle P, Grubb A. New markers for the determination of GFR: iohexol clearance and cystatin C serum concentration. Kidney Int Suppl. 1994;47:S17–S19
  25. Sterner G, Frennby B, Mansson S, Ohlsson A, Prutz KG, Almen T. Assessing residual renal function and efficiency of hemodialysis—an application for urographic contrast media. Nephron. 2000;85(4):324–333
  26. Frennby B, Sterner G, Almen T, Hagstam KE, Hultberg B, Jacobsson L. The use of iohexol clearance to determine GFR in patients with severe chronic renal failure—a comparison between different clearance techniques. Clin Nephrol. 1995;43(1):35–46
  27. Falkner B, Daniels SR. Summary of the Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents. Hypertension. 2004;44(4):387–388
  28. Mitsnefes M, Ho PL, McEnery PT. Hypertension and progression of chronic renal insufficiency in children: a report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS). J Am Soc Nephrol. 2003;14(10):2618–2622
  29. National Kidney Foundation. III. KDOQI Clinical Practice Recommendations for Anemia in Chronic Kidney Disease in Children. Am J Kidney Dis. 2006;47(5 suppl 3):S86–S108
  30. Stone P, Richards M, Hardy J. Fatigue in patients with cancer. Eur J Cancer. 1998;34(11):1670–1676
  31. Hockenberry MJ, Hinds PS, Barrera P, et al. Three instruments to assess fatigue in children with cancer: the child, parent and staff perspectives. J Pain Symptom Manage. 2003;25(4):319–328
  32. Petersen S, Bergstrom E, Brulin C. High prevalence of tiredness and pain in young schoolchildren. Scand J Public Health. 2003;31(5):367–374
  33. Nagane M. Relationship of subjective chronic fatigue to academic performance. Psychol Rep. 2004;95(1):48–52
  34. Wilson A, Yu HT, Goodnough LT, Nissenson AR. Prevalence and outcomes of anemia in rheumatoid arthritis: a systematic review of the literature. Am J Med. 2004;116(suppl 7A):50S–57S
  35. Jhamb M, Weisbord SD, Steel JL, Unruh M. Fatigue in patients receiving maintenance dialysis: a review of definitions, measures, and contributing factors. Am J Kidney Dis. 2008;52(2):353–365
  36. McKenna AM, Keating LE, Vigneux A, Stevens S, Williams A, Geary DF. Quality of life in children with chronic kidney disease—patient and caregiver assessments. Nephrol Dial Transplant. 2006;21(7):1899–1905
  37. Goldstein SL, Gerson AC, Goldman CW, Furth S. Quality of life for children with chronic kidney disease. Semin Nephrol. 2006;26(2):114–117
  38. Naughton MJ, Ruggiero AM, Lawrence JM, et al. Health-related quality of life of children and adolescents with type 1 or type 2 diabetes mellitus: SEARCH for Diabetes in Youth Study. Arch Pediatr Adolesc Med. 2008;162(7):649–657
  39. Varni JW, Limbers CA. The PedsQL Multidimensional Fatigue Scale in young adults: feasibility, reliability and validity in a university student population. Qual Life Res. 2008;17(1):105–114
  40. Chervin RD, Hedger K, Dillon JE, Pituch KJ. Pediatric Sleep Questionnaire (PSQ): validity and reliability of scales for sleep-disordered breathing, snoring, sleepiness, and behavioral problems. Sleep Med. 2000;1(1):21–32
  41. Owens JA, Spirito A, McGuinn M. The Children's Sleep Habits Questionnaire (CSHQ): psychometric properties of a survey instrument for school-aged children. Sleep. 2000;23(8):1043–1051
  42. Archbold KH, Pituch KJ, Panahi P, Chervin RD. Symptoms of sleep disturbances among children at two general pediatric clinics. J Pediatr. 2002;140(1):97–102
  43. Camhi SL, Morgan WJ, Pernisco N, Quan SF. Factors affecting sleep disturbances in children and adolescents. Sleep Med. 2000;1(2):117–123
  44. Viner R, Christie D. Fatigue and somatic symptoms. BMJ. 2005;330(7498):1012–1015
  45. ter Wolbeek M, van Doornen LJ, Kavelaars A, Heijnen CJ. Severe fatigue in adolescents: a common phenomenon?. Pediatrics. 2006;117(6):e1078–e1086

 Originally published online as doi:10.1053/j.ajkd.2009.09.021 on December 25, 2009.

PII: S0272-6386(09)01307-9

doi: 10.1053/j.ajkd.2009.09.021

American Journal of Kidney Diseases
Volume 55, Issue 2 , Pages 269-280 , February 2010