American Journal of Kidney Diseases
Volume 55, Issue 1 , Pages 88-99 , January 2010

Effect of Intradialytic Versus Home-Based Aerobic Exercise Training on Physical Function and Vascular Parameters in Hemodialysis Patients: A Randomized Pilot Study

  • Kirsten P. Koh, BHM(Hons)

      Affiliations

    • School of Human Life Sciences, University of Tasmania, Launceston, Tasmania, Australia
    • ,
  • Robert G. Fassett, PhD

      Affiliations

    • School of Human Movement Studies, The University of Queensland, St. Lucia, Queensland, Australia
    • Renal Research Tasmania, Launceston General Hospital, Charles St. Launceston, Tasmania, Australia
    • Renal Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia
    • School of Medicine, University of Queensland, Brisbane, Queensland, Australia
    • ,
  • James E. Sharman, PhD

      Affiliations

    • Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    • ,
  • Jeff S. Coombes, PhD

      Affiliations

    • School of Human Movement Studies, The University of Queensland, St. Lucia, Queensland, Australia
    • Renal Research Tasmania, Launceston General Hospital, Charles St. Launceston, Tasmania, Australia
    • ,
  • Andrew D. Williams, PhD

      Affiliations

    • School of Human Life Sciences, University of Tasmania, Launceston, Tasmania, Australia
    • Corresponding Author InformationAddress correspondence to Andrew D. Williams, PhD, School of Human Life Sciences, University of Tasmania, Locked Bag 1320, Launceston, Tasmania, 7250 Australia

Received 21 April 2009 ,Accepted 14 September 2009.

References 

  1. Johansen KL, Chertow GM, Ng AV, et al. Physical activity levels in patients on haemodialysis and healthy sedentary controls. Kidney Int. 2000;57(6):2564–2570
  2. Sietsema KE, Amato A, Adler SG, Brass EP. Exercise capacity as a predictor of survival among ambulatory patients with end-stage renal disease. Kidney Int. 2004;65(2):719–724
  3. Storer TW, Casaburi R, Sawelson S, Kopple JD. Endurance exercise training during haemodialysis improves strength, power, fatigability and physical performance in maintenance haemodialysis patients. Nephrol Dial Transplant. 2005;20(7):1429–1437
  4. Kouidi E, Grekas D, Deligiannis A, Tourkantonis A. Outcomes of long-term exercise training in dialysis patients: comparison of two training programs. Clin Nephrol. 2004;61(suppl 1):S31–S38
  5. Van Vilsteren MCBA, De Greef MHG, Huisman RM. The effects of a low-to-moderate intensity pre-conditioning exercise programme linked with exercise counselling for sedentary haemodialysis patients in The Netherlands: results of a randomised clinical trial. Nephrol Dial Transplant. 2005;20(1):141–146
  6. Tetzner F, Scholze A, Wittstock A, Zidek W, Tepel M. Impaired vascular reactivity in patients with chronic kidney disease. Am J Nephrol. 2008;28(2):218–223
  7. Briet M, Bozec E, Laurent S, et al. Arterial stiffness and enlargement in mild-to-moderate chronic kidney disease. Kidney Int. 2006;69(2):350–357
  8. Wang MC, Tsai WC, Chen JY, Huang JJ. Stepwise increase in arterial stiffness corresponding with the stages of chronic kidney disease. Am J Kidney Dis. 2005;45(3):494–501
  9. Hambrecht R, Adams V, Erbs S, et al. Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation. 2003;107(25):3152–3158
  10. Tanaka H, Dinenno FA, Monahan KD, Clevenger CM, De Souza CA, Seals DR. Aging, habitual exercise, and dynamic arterial compliance. Circulation. 2000;102(11):1270–1275
  11. Vaitkevicius PV, Fleg JL, Engel JH, et al. Effects of age and aerobic capacity on arterial stiffness in healthy adults. Circulation. 1993;88(4 pt 1):1456–1462
  12. Edwards DG, Schofield RS, Magyari PM, Nichols WW, Braith RW. Effect of exercise training on central aortic pressure wave reflection in coronary artery disease. Am J Hypertens. 2004;17(6):540–543
  13. London GM, Marchais SJ, Guerin AP, Metivier F, Adda H. Arterial structure and function in end-stage renal disease. Nephrol Dial Transplant. 2002;17(10):1713–1724
  14. Laurent S, Cockcroft J, Van Bortel L, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006;27(21):2588–2605
  15. Blacher J, Guerin AP, Pannier B, Marchais SJ, Safar ME, London GM. Impact of aortic stiffness on survival in end-stage renal disease. Circulation. 1999;99(18):2434–2439
  16. Barenbrock M, Spieker C, Laske V, et al. Effect of long-term hemodialysis on arterial compliance in end-stage renal failure. Nephron. 1993;65(2):249–253
  17. London GM, Guerin AP, Marchais SJ, et al. Cardiac and arterial interactions in end-stage renal disease. Kidney Int. 1996;50(2):600–608
  18. Mustata S, Chan C, Lai V, Miller JA. Impact of an exercise program on arterial stiffness and insulin resistance in hemodialysis patients. J Am Soc Nephrol. 2004;15(10):2713–2718
  19. Toussaint ND, Polkinghorne KR, Kerr PG. Impact of intradialytic exercise on arterial compliance and B-type natriuretic peptide levels in hemodialysis patients. Hemodial Int. 2008;12(2):254–263
  20. Koh KP, Fassett RG, Sharman JE, Coombes JS, Williams AD. Intradialytic versus home based exercise training in hemodialysis patients: a randomised controlled trial. BMC Nephrol. 2009;10(1):2
  21. US Department of Health and Human Services. Physical Activity and Health: A Report of the Surgeon General. Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion; 1996;
  22. Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc. 1982;14(5):377–381
  23. Wilkinson IB, Fuchs SA, Jansen IM, et al. Reproducibility of pulse wave velocity and augmentation index measured by pulse wave analysis. J Hypertens. 1998;16(12 pt 2):2079–2084
  24. Frimodt-Moller M, Nielsen AH, Kamper AL, Strandgaard S. Reproducibility of pulse-wave analysis and pulse-wave velocity determination in chronic kidney disease. Nephrol Dial Transplant. 2008;23(2):594–600
  25. Chen C-H, Nevo E, Fetics BE, et al. Estimation of central aortic pressure waveform by mathematical transformation of radial tonometry pressure: validation of generalised transfer function. Circulation. 1997;95(7):1827–1836
  26. Fassett RG, Robertson IK, Geraghty DP, Ball MJ, Burton NW, Coombes JS. Physical activity levels in chronic kidney disease patients entering the LORD trial. Med Sci Sports Exerc. 2009;41(5):985–991
  27. Timperio A, Salmon J, Crawford D. Validity and reliability of a physical activity recall instrument among overweight and non-overweight men and women. J Sci Med Sport. 2003;6(4):477–491
  28. Brown WJ, Trost SG, Bauman A, Mummery K, Owen N. Test-retest reliability of four physical activity measures used in population surveys. J Sci Med Sport. 2004;7(2):205–215
  29. Ware JE, Snow KK, Kosinski M, Gandek B. SF-36 Health Survey Manual and Interpretation Guide. Boston, MA: The Health Institute, New England Medical Center; 1997;
  30. Painter P, Carlson L, Carey S, Paul SM, Myll S. Physical functioning and health-related quality of life changes with exercise training in hemodialysis patients. Am J Kidney Dis. 2000;35(3):482–492
  31. Knight EL, Ofsthun N, Teng M, Lazarus JM, Curhan GC. The association between mental health, physical function, and hemodialysis mortality. Kidney Int. 2003;63(5):1843–1851
  32. Kodis J, Smith KM, Arthur HM, Daniels C, Suskin N, McKelvie RS. Changes in exercise capacity and lipids after clinic versus home-based aerobic training in coronary artery bypass graft surgery patients. J Cardiopulm Rehabil. 2001;21(1):31–36
  33. Bendermacher BL, Willigendael EM, Teijink JA, Prins MH. Supervised exercise therapy versus non-supervised exercise therapy for intermittent claudication. Cochrane Database Syst Rev. 2006;(2):CD005263
  34. Jamal SA, Leiter RE, Jassal V, Hamilton CJ, Bauer DC. Impaired muscle strength is associated with fractures in hemodialysis patients. Osteoporos Int. 2006;17(9):1390–1397
  35. Isles RC, Choy NLL, Steer M, Nitz JC. Normal values of balance tests in women aged 20-80. J Am Geriat Soc. 2004;52(8):1367–1372
  36. Ferrier KE, Waddell TK, Gatzka CD, Cameron JD, Dart AM, Kingwell BA. Aerobic exercise training does not modify large-artery compliance in isolated systolic hypertension. Hypertension. 2001;38(2):222–226
  37. Westhoff TH, Franke N, Schmidt S, et al. Too old to benefit from sports? (The cardiovascular effects of exercise training in elderly subjects treated for isolated systolic hypertension). Kidney Blood Press Res. 2007;30(4):240–247
  38. Hayashi K, Sugawara J, Komine H, Maeda S, Yokoi T. Effects of aerobic exercise training on the stiffness of central and peripheral arteries in middle-aged sedentary men. Jpn J Physiol. 2005;55(4):235–239
  39. Kakiyama T, Sugawara J, Murakami H, Maeda S, Kuno S, Matsuda M. Effects of short-term endurance training on aortic distensibility in young males. Med Sci Sports Exerc. 2005;37(2):267–271
  40. Canadian Erythropoietin Study Group. Association between recombinant human erythropoietin and quality of life and exercise capacity of patients receiving haemodialysis (Canadian Erythropoietin Study Group). BMJ. 1990;300(6724):573–578

 Originally published online as doi:10.1053/j.ajkd.2009.09.025 on November 23, 2009.

 Trial registration: www.anzctr.org.au; study number: ACTRN12608000247370.

PII: S0272-6386(09)01311-0

doi: 10.1053/j.ajkd.2009.09.025

American Journal of Kidney Diseases
Volume 55, Issue 1 , Pages 88-99 , January 2010

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