American Journal of Kidney Diseases
Volume 55, Issue 2 , Pages 259-268 , February 2010

Is Presence of ANCA in Crescentic IgA Nephropathy a Coincidence or Novel Clinical Entity? A Case Series

  • Christos Bantis, MD

      Affiliations

    • Department of Nephrology, Heinrich-Heine University of Düsseldorf, Germany
    • Department of Nephrology, Aristotle University of Thessaloniki, Greece
    • ,
  • Maria Stangou, MD

      Affiliations

    • Department of Nephrology, Aristotle University of Thessaloniki, Greece
    • ,
  • Christoph Schlaugat, MD

      Affiliations

    • Department of Nephrology, Städisches Klinikum Solingen, University of Cologne, Germany
    • ,
  • Efstathios Alexopoulos, MD, PhD

      Affiliations

    • Deceased.
    • Department of Nephrology, Aristotle University of Thessaloniki, Greece
    • ,
  • Aphroditi Pantzaki, MD

      Affiliations

    • Department of Nephrology, Aristotle University of Thessaloniki, Greece
    • ,
  • Dimitrios Memmos, MD, PhD

      Affiliations

    • Department of Nephrology, Aristotle University of Thessaloniki, Greece
    • ,
  • Katrin Ivens, MD, PhD

      Affiliations

    • Department of Nephrology, Heinrich-Heine University of Düsseldorf, Germany
    • ,
  • Peter J. Heering, MD, PhD

      Affiliations

    • Department of Nephrology, Heinrich-Heine University of Düsseldorf, Germany
    • Department of Nephrology, Städisches Klinikum Solingen, University of Cologne, Germany
    • Corresponding Author InformationAddress correspondence to Peter J. Heering, MD, PhD, Department of Nephrology, Staedtisches Klinikum Solingen, Gotenstrasse 1, 42653 Solingen, Germany

Received 31 March 2009 ,Accepted 28 September 2009.

References 

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  3. Mestecky J, Tomana M, Crowley-Nowick PA, Moldoveanu Z, Julian BA, Jackson S. Defective galactosylation and clearance of IgA1 molecules as a possible etiopathogenic factor in IgA nephropathy. Contrib Nephrol. 1993;104:172–182
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  9. McGregor D, Lynn KL, Robson R. Rapidly progressive IgA nephropathy with anti-myeloperoxidase antibodies responding to immunosuppression. Clin Nephrol. 1998;50(1):64
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  13. Lui SL, Chan KW, Yip PS, Chan TM, Lai KN, Lo WK. Simultaneous occurrence of diabetic glomerulosclerosis, IgA nephropathy, crescentic glomerulonephritis, and myeloperoxidase-antineutrophil cytoplasmic antibody seropositivity in a Chinese patient. Am J Kidney Dis. 2002;40(4):E14
  14. Jimbo R, Ubara Y, Tagami T, et al. A pediatric occurrence of crescentic glomerulonephritis associated with antineutrophil cytoplasmic antibodies and mesangial IgA deposits. Clin Nephrol. 2007;68(2):104–108
  15. Ogawa N, Yano S, Yamane Y, et al. MPO-ANCA-positive IgA nephropathy successfully treated with tonsillectomy. Clin Exp Nephrol. 2007;11(4):326–331
  16. Hagen EC, Daha MR, Hermans J, et al. Diagnostic value of standardized assays for anti-neutrophil cytoplasmic antibodies in idiopathic systemic vasculitis (EC/BCR Project for ANCA Assay Standardization). Kidney Int. 1998;53(3):743–753
  17. Xiao H, Heeringa P, Hu P, et al. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J Clin Invest. 2002;110(7):955–963
  18. Han WK, Choi HK, Roth RM, McCluskey RT, Niles JL. Serial ANCA titers: useful tool for prevention of relapses in ANCA-associated vasculitis. Kidney Int. 2003;63(3):1079–1085
  19. Waldherr R, Rambausek M, Duncker WD, Ritz E. Frequency of mesangial IgA deposits in a non-selected autopsy series. Nephrol Dial Transplant. 1989;4(11):943–946
  20. Lai FM, Li EK, Suen MW, Lui SF, Li PK, Lai KN. Pulmonary hemorrhage (A fatal manifestation in IgA nephropathy). Arch Pathol Lab Med. 1994;118(5):542–546
  21. Medcalf JF, Brownjohn AM, Turney JH. Pulmonary haemorrhage in association with IgA nephropathy. Nephrol Dial Transplant. 1996;11(6):1148–1149
  22. Levy JB, Hammad T, Coulthart A, Dougan T, Pusey CD. Clinical features and outcome of patients with both ANCA and anti-GBM antibodies. Kidney Int. 2004;66(4):1535–1540

 Originally published online as doi:10.1053/j.ajkd.2009.09.031 on December 31, 2009.

PII: S0272-6386(09)01321-3

doi: 10.1053/j.ajkd.2009.09.031

American Journal of Kidney Diseases
Volume 55, Issue 2 , Pages 259-268 , February 2010

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