American Journal of Kidney Diseases
Volume 55, Issue 2 , Pages 326-334 , February 2010

Secondary Hyperparathyroidism and Anemia in Children Treated by Hemodialysis

  • Lorie B. Smith, MD, MHS

      Affiliations

    • Division of Pediatric Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD
    • Corresponding Author InformationAddress correspondence to Lorie B. Smith, MD, MHS, 200 N Wolfe St, Rm 3055, Baltimore, MD 21287
  • ,
  • Jeffrey J. Fadrowski, MD, MHS

      Affiliations

    • Division of Pediatric Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD
  • ,
  • Chanelle J. Howe, PhD, MHS, MPH

      Affiliations

    • Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
  • ,
  • Barbara A. Fivush, MD

      Affiliations

    • Division of Pediatric Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD
  • ,
  • Alicia M. Neu, MD

      Affiliations

    • Division of Pediatric Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD
  • ,
  • Susan L. Furth, MD, PhD

      Affiliations

    • Division of Pediatric Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD

Received 6 May 2009 ,Accepted 28 September 2009.

References 

  1. National Kidney Foundation. KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Anemia in Chronic Kidney Disease: 2007 update of hemoglobin target. Am J Kidney Dis. 2007;50(3):471–529
  2. Mitsnefes MM, Daniels SR, Schwartz SM, Meer RA, Khoury P, Strife CF. Severe left ventricular hypertrophy in pediatric dialysis: prevalence and predictors. Pediatr Nephrol. 2000;14:898–902
  3. Eknoyan G. The importance of early treatment of the anemia of chronic kidney disease. Nephrol Dial Transplant. 2001;16(suppl 5):S45–S49
  4. Dowling T. Prevalence, etiology, and consequences of anemia and clinical and economic benefits of anemia correction in patients with chronic kidney disease: an overview. Am J Health Syst Pharm. 2007;64(suppl 8):S3–S7
  5. Amaral S, Hwang W, Fivush B, Neu A, Frankenfield D, Furth S. Association of mortality and hospitalization with achievement of adult hemoglobin targets in adolescents maintained on hemodialysis. J Am Soc Nephrol. 2006;17:2878–2885
  6. Drueke T. Hyporesponsiveness to recombinant human erythropoietin. Nephrol Dial Transplant. 2001;16:25–28
  7. Tutal E, Sezer S, Afsar B, Arat Z, Ozdemir FN, Haberal M. Additional effects of hyperparathyroidism on inflammatory status and rHuEpo requirements in hemodialysis patients. Transplant Proc. 2006;38:2807–2812
  8. Brancaccio D, Cozzolino M, Gallieni M. Hyperparathyroidism and anemia in uremic subjects: a combined therapeutic approach. J Am Soc Nephrol. 2004;15(suppl 1):S21–S24
  9. Drueke T, Eckardt K. Role of secondary hyperparathyroidism in erythropoietin resistance of chronic renal failure patients. Nephrol Dial Transplant. 2002;17:28–31
  10. Zingraff J, Drueke T, Marie P, Man NK, Jungers P, Bordier P. Anemia and secondary hyperparathyroidism. Arch Intern Med. 1978;138:1650–1652
  11. Kalantar-Zadeh K, McAllister C, Lenn R, Lee G, Nissenson A, Kopple J. Effect of malnutrition-inflammation complex syndrome on EPO hyporesponsiveness in maintenance hemodialysis patients. Am J Kidney Dis. 2003;42:761–773
  12. Center for Medicare & Medicaid Services. 2002 annual report: ESRD clinical performance measures project. Am J Kidney Dis. 2003;42(suppl 2):S1–S96
  13. Dickerson RN, Alexander KH, Minard G, Croce MA, Brown RO. Accuracy of methods to estimate ionized and “corrected” serum calcium concentrations in critically ill multiple trauma patients receiving specialized nutrition support. J Parenter Enteral Nutr. 2004;28:133–141
  14. Daugirdas JT. Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. J Am Soc Nephrol. 1993;4:1205–1213
  15. Goldstein AL. Prescribing and monitoring hemodialysis. In:  Warady BA,  Schaefer FS,  Fine RN,  Alexander SR editor. Pediatric Dialysis. Boston, MA: Kluwer Academic Publishers; 2004;p. 135–145
  16. National Kidney Foundation. KDOQI Clinical Practice Guidelines for Bone Metabolism and Disease in Chronic Kidney Disease. Am J Kidney Dis. 2003;42(suppl 3):S1–S170
  17. Centers for Medicare & Medicaid Services. 2005 Annual Report, End Stage Renal Disease Clinical Performance Measures Project. Baltimore, MD: Department of Health and Human Services, Centers for Medicare & Medicaid Services, Office of Clinical Standards & Quality; December 2005;
  18. Juarez-Congelosi M, Orellana P, Goldstein S. Normalized protein catabolic rate versus serum albumin as a nutrition status marker in pediatric patients receiving hemodialysis. J Ren Nutr. 2007;17(4):269–274
  19. Greenland S, Finkle W. A critical look at methods for handling missing covariates in epidemiologic regression analyses. Am J Epidemiol. 1995;142:1255–1264
  20. Royston P. Multiple imputation of missing values: update of ICE. Stata J. 2004;5(4):527–536
  21. Spiegelman D, Hertzmark E. Easy SAS calculations for risk or prevalence ratios and differences. Am J Epidemiol. 2005;162:199–200
  22. Zou G. A modified Poisson regression approach to prospective studies with binary data. Am J Epidemiol. 2003;159:702–706
  23. Coen G, Calabria S, Bellingham G, et al. Parathyroidectomy in chronic renal failure: short and long-term results in parathyroid function, blood pressure, and anemia. Nephron. 2001;88:149–155
  24. Seeherunvong W, Rubio L, Abitbol C, et al. Identification of poor responders to erythropoietin among children undergoing hemodialysis. J Pediatr. 2001;138(no. 5):710–712
  25. Belsha C, Berry P. Effect of hyperparathyroidism on response to erythropoietin in children on dialysis. Pediatr Nephrol. 1998;12:298–303
  26. Wei M, Bargman J, Oreopoulos D. Factors related to erythropoietin hyporesponsiveness in patients on chronic peritoneal dialysis. Int Urol Nephrol. 2007;39:935–940
  27. Agarwal R, Davis J, Smith L. Serum albumin is strongly associated with erythropoietin sensitivity in hemodialysis patients. Clin J Am Soc Nephrol. 2008;3:98–104
  28. Tonelli M, Blake P, Muirhead N. Predictors of erythropoietin responsiveness in chronic hemodialysis patients. ASAIO J. 2001;47(1):82–85
  29. Madore F, Lowrie E, Brugnara C, et al. Anemia in hemodialysis patients: variables affecting this outcome predictor. J Am Soc Nephrol. 1997;8(12):1921–1929
  30. Paniichi V, Manca-Rizza G, Paoletti S, et al. Effects on inflammatory and nutritional markers of haemodiafiltration with online regeneration of ultrafiltrate (HFR) vs online haemodiafiltration; a cross-over randomized multicentre trial. Nephrol Dial Transplant. 2006;21:756–762
  31. Carvalho KT, Silva MI, Bregman R. Nutritional profile of patients with chronic kidney failure. J Ren Nutr. 2004;14:97–100

PII: S0272-6386(09)01420-6

doi: 10.1053/j.ajkd.2009.09.033

American Journal of Kidney Diseases
Volume 55, Issue 2 , Pages 326-334 , February 2010