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American Journal of Kidney Diseases
Volume 55, Issue 2
, Pages 365-385
, February 2010
The Management of Diabetic Neuropathy in CKD
References
- . Employer-paid nonmedical costs for patients with diabetes and end-stage renal disease [abstract]. Prev Chronic Dis. 2006;3(3):83A;http://www.cdc.gov/pcd/issues/2006/jul/05_0210.htmAccessed September 1, 2009
- . Risk factors for non-ischaemic foot ulceration in diabetic nephropathy. Diabet Med. 1991;8(3):223–225
- . Autonomic neuropathy and survival in diabetes mellitus: effects of pancreas transplantation. Diabetologia. 1991;34(suppl 1):S108–S112
- . Mortality in diabetic patients with cardiovascular autonomic neuropathy. Diabet Med. 1993;10(9):820–824
- . Progression of diabetic autonomic neuropathy over a decade in insulin-dependent diabetics. Q J Med. 1990;75(278):635–646
- . How can the cardiac death rate be reduced in dialysis patients?. Semin Dial. 2002;15(1):18–20
- . Dialysis patient outcomes in Europe vs the USA (Why do Europeans live longer?). Nephrol Dial Transplant. 1997;12(9):1816–1819
- Survival and development of cardiovascular disease by modality of treatment in patients with end-stage renal disease. J Am Soc Nephrol. 2001;12(11):2411–2417
- . USRDS 2006 Annual Data Report: Atlas of End-Stage Renal Disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2006;
- . Heart rate variability (HRV) in kidney failure: measurement and consequences of reduced HRV. Nephrol Dial Transplant. 2008;23(2):444–449
- Autonomic dysregulation in patients awaiting kidney transplantation. Am J Kidney Dis. 1998;32(2):221–229
- . Importance of cardiovascular autonomic dysfunction in IDDM subjects with diabetic nephropathy. Diabetes Care. 1989;12(4):259–264
- . The role of autonomic neuropathy in the genesis of intradialytic hypotension. Am J Nephrol. 2001;21(5):357–361
- . Does dialysis therapy improve autonomic and peripheral nervous system abnormalities in chronic uraemia?. J Intern Med. 2000;248(1):21–26
- Autonomic neuropathy and secondary hyperparathyroidism in uraemia. Nephrol Dial Transplant. 1990;5(suppl 1):S128–S130
- Reduced baroreflex effectiveness index in hypertensive patients with chronic renal failure. Am J Hypertens. 2005;18(7):995–1000discussion 1016
- . Neurological complications in renal failure: a review. Clin Neurol Neurosurg. 2004;107(1):1–16
- . Pain assessment and management for a dialysis patient with diabetic peripheral neuropathy. CANNT J. 2006;16(2):12–1720-16; quiz 18-19, 27-18
- . Cardiovascular autonomic neuropathy (expiration and inspiration ratio) in type 1 diabetes (Incidence and predictors). J Diabetes Complications. 2000;14(1):1–6
- . Risk factors for cardiac autonomic neuropathy in type 1 diabetes mellitus. Diabetologia. 2005;48(1):164–171
- . Activity-dependent excitability changes suggest Na+/K+ pump dysfunction in diabetic neuropathy. Brain. 2008;131(pt 5):1209–1216
- . Impaired energy utilization and Na-K-ATPase in diabetic peripheral nerve. Am J Physiol. 1984;246:E311–E318
- . Diabetic neuropathy: mechanisms to management. Pharmacol Ther. 2008;120(1):1–34
- . Diabetic neuropathy and oxidative stress. Diabetes Metab Res Rev. 2006;22(4):257–273
- . Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414(6865):813–82013
- . The pathobiology of diabetic complications: a unifying mechanism. Diabetes. 2005;54(6):1615–1625
- . Parathyroid hormone: a uremic toxin. Adv Exp Med Biol. 1987;223:1–17
- . Parathyroid hormone metabolism and its potential as a uremic toxin. Am J Physiol. 1980;239(1):F1–F12
- . Uremic toxicity: the middle molecule hypothesis revisited. Semin Nephrol. 1994;14(3):205–218
- . Ouabain reverses conduction disturbances in single demyelinated nerve fibers. Neurology. 1989;39(10):1364–1368
- . Altered motor nerve excitability in end-stage kidney disease. Brain. 2005;128(pt 9):2164–2174
- . Ischaemia induces paradoxical changes in axonal excitability in end-stage kidney disease. Brain. 2006;129(pt 6):1585–1592
- . Abnormal sodium channel distribution in optic nerve axons in a model of inflammatory demyelination. Brain. 2003;126(pt 7):1552–1561
- . Nerve excitability changes in chronic renal failure indicate membrane depolarization due to hyperkalaemia. Brain. 2002;125(pt 6):1366–1378
- . Uremic neuropathy: clinical features and new pathophysiological insights. Muscle Nerve. 2007;35(3):273–290
- Sympathetic overactivity in patients with chronic renal failure. N Engl J Med. 1992;327(27):1912–1918
- . Is kidney ischemia the central mechanism in parallel activation of the renin and sympathetic system?. J Hypertens. 2009;27(7):1341–1349
- . Spectral analysis of fluctuations in heart rate: an objective evaluation of autonomic nervous control in chronic renal failure. Nephron. 1987;45(3):202–206
- . Mechanisms of autonomic nervous system dysfunction in uremia. Kidney Int. 1981;20(2):246–253
- . Elevation of serum and ventricular norepinephrine content in the diabetic rat. Res Commun Chem Pathol Pharmacol. 1981;33(3):559–562
- . Antioxidants and myocardial contractility: illuminating the “dark side” of beta-adrenergic receptor activation?. Circulation. 2001;103(6):782–783
- . Effects of streptozotocin diabetes on the noradrenergic innervation of the rat heart: a longitudinal histofluorescence and neurochemical study. Brain Res Bull. 1982;8(6):593–607
- cAMP-dependent phosphorylation of the nuclear encoded 18-kDa (IP) subunit of respiratory complex I and activation of the complex in serum-starved mouse fibroblast cultures. J Biol Chem. 2000;275(23):17578–17582
- . Alpha- and beta-adrenergic pathways differentially regulate cell type-specific apoptosis in rat cardiac myocytes. Circulation. 1999;100(3):305–311
- . Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the beta-adrenergic pathway. Circulation. 1998;98(13):1329–1334
- . Use of heart rate reserve and rating of perceived exertion to prescribe exercise intensity in diabetic autonomic neuropathy. Diabetes Care. 2003;26(4):986–990
- . Differences in heart rate variability parameters during the post-dialytic period in type II diabetic and non-diabetic ESRD patients. Nephrol Dial Transplant. 2001;16(3):566–573
- . The natural history of diabetic autonomic neuropathy. Q J Med. 1980;49(193):95–108
- . Diagnosis and management of diabetic autonomic neuropathy. Br Med J. 1982;285(6346):916–918
- . Diabetic autonomic neuropathy: present insights and future prospects. Diabetes Care. 1986;9(6):648–665
- . Diabetic cardiovascular autonomic neuropathy. Circulation. 2007;115(3):387–397
- Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy (The Consensus Committee of the American Autonomic Society and the American Academy of Neurology). Neurology. 1996;46(5):1470
- . Autonomic insufficiency in uremia as a cause of hemodialysis-induced hypotension. N Engl J Med. 1974;290(12):650–653
- Autonomic insufficiency as a factor contributing to dialysis-induced hypotension. Nephrol Dial Transplant. 2001;16(8):1657–1662
- . No change in automatic function tests during uncomplicated haemodialysis. Nephrol Dial Transplant. 1996;11(4):651–656
- Effects of autonomic neuropathy on coronary blood flow in patients with diabetes mellitus. Circulation. 1999;100(8):813–819
- Effects of cardiac sympathetic innervation on coronary blood flow. N Engl J Med. 1997;336(17):1208–1215
- Scintigraphic assessment of regionalized defects in myocardial sympathetic innervation and blood flow regulation in diabetic patients with autonomic neuropathy. J Am Coll Cardiol. 1998;31(7):1575–1584
- . Impairment of coronary vascular reserve and ACh-induced coronary vasodilation in diabetic patients with angiographically normal coronary arteries and normal left ventricular systolic function. Diabetes. 1993;42(7):1017–1025
- . [Coronary vasoconstriction induced by acetylcholine in young smokers with normal angiographic coronary vessels]. Arch Mal Coeur Vaiss. 1993;86(8):1133–1136
- . Metaiodobenzylguanidine imaging in diabetes mellitus: assessment of cardiac sympathetic denervation and its relation to autonomic dysfunction and silent myocardial ischemia. J Am Coll Cardiol. 1995;25(3):610–618
- Sudden cardiac death (Nonpharmacologic interventions). Circulation. 1987;76(1 pt 2):I215–I219
- . Sudden cardiac death (Support for a role of triggering in causation). Circulation. 1993;87(5):1442–1450
- . Neural activity and ventricular fibrillation. N Engl J Med. 1976;294(21):1165–1170
- . The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis. Diabetes Care. 2003;26(6):1895–1901
- . Left ventricular hypertrophy as a predictor of coronary heart disease mortality and the effect of hypertension. Am Heart J. 2000;140(6):848–856
- . Risk of ventricular arrhythmias in left ventricular hypertrophy: the Framingham Heart Study. Am J Cardiol. 1987;60(7):560–565
- Association between cardiovascular autonomic neuropathy and left ventricular hypertrophy in diabetic haemodialysis patients. Nephrol Dial Transplant. 2004;19(10):2532–2538
- . Effect of age and gender on sudomotor and cardiovagal function and blood pressure response to tilt in normal subjects. Muscle Nerve. 1997;20(12):1561–1568
- . Cardiovascular autonomic nervous system tests: determination of normative values and effect of confounding variables. J Auton Nerv Syst. 1997;62(1-2):40–44
- Heart rate variability: standards of measurement, physiological interpretation and clinical use (Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology). Circulation. 1996;93(5):1043–1065
- Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care. 2005;28(4):956–962
- . Carbon-11 hydroxyephedrine with positron emission tomography for serial assessment of cardiac adrenergic neuronal function after acute myocardial infarction in humans. J Am Coll Cardiol. 1993;22(2):368–375
- Cardiac sympathetic dysinnervation in diabetes: implications for enhanced cardiovascular risk. Circulation. 1998;98(10):961–968
- . Regression and progression of cardiac sympathetic dysinnervation complicating diabetes: an assessment by C-11 hydroxyephedrine and positron emission tomography. Metabolism. 1999;48(1):92–101
- Myocardial m-[123I]iodobenzylguanidine scintigraphy for the assessment of adrenergic cardiac innervation in patients with IDDM (Comparison with cardiovascular reflex tests and relationship to left ventricular function). Diabetes. 1995;44(5):543–549
- . Scintigraphic evidence for cardiac sympathetic dysinnervation in long-term IDDM patients with and without ECG-based autonomic neuropathy. Diabetologia. 1995;38(11):1345–1352
- . Reduced myocardial 123I-metaiodobenzylguanidine uptake in newly diagnosed IDDM patients. Diabetes. 1996;45(6):801–805
- . Increased QT dispersion and cardiac adrenergic dysinnervation in diabetic patients with autonomic neuropathy. Am J Cardiol. 1996;78(9):1057–1059
- . Demonstration of regional sympathetic denervation of the heart in diabetes (Comparison between patients with NIDDM and IDDM). Diabetes Care. 1996;19(10):1083–1090
- Sympathetic dysfunction in type 1 diabetes: association with impaired myocardial blood flow reserve and diastolic dysfunction. J Am Coll Cardiol. 2004;44(12):2368–2374
- . Myocardial kinetics of carbon-11-meta-hydroxyephedrine: retention mechanisms and effects of norepinephrine. J Nucl Med. 1993;34(8):1287–1293
- Evidence for regional catecholamine uptake and storage sites in the transplanted human heart by positron emission tomography. J Clin Invest. 1991;87(5):1681–1690
- Regional in vivo and in vitro characterization of autonomic innervation in cardiomyopathic human heart. Circulation. 1998;97(2):174–180
- . Automated quantification of sympathetic beat-by-beat activity, independent of signal quality. J Appl Physiol. 2001;91(3):1199–1206
- . Reduction of gangrene and amputations in diabetic renal transplant patients: the role of a special foot clinic. Diabet Med. 1995;12(7):632–635
- . Nontraumatic lower extremity amputations in the Medicare end-stage renal disease population. Kidney Int. 1999;56(4):1524–1533
- The burden of amputation among hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS). Am J Kidney Dis. 2009;54(4):680–692
- Report and recommendations of the San Antonio Conference on Diabetic Neuropathy (American Diabetes Association). Muscle Nerve. 1988;11(7):661–667
- . Diabetic somatic neuropathies. Diabetes Care. 2004;27(6):1458–1486
- . Critical review of oral drug treatments for diabetic neuropathic pain-clinical outcomes based on efficacy and safety data from placebo-controlled and direct comparative studies. Diabetes Metab Res Rev. 2005;21(3):231–240
- . The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus (The Diabetes Control and Complications Trial Research Group). N Engl J Med. 1993;329:977–986
- . Effect of intensive diabetes treatment on nerve conduction in the Diabetes Control and Complications Trial. Ann Neurol. 1995;38(6):869–880
- . The effect of intensive diabetes therapy on measures of autonomic nervous system function in the Diabetes Control and Complications Trial (DCCT). Diabetologia. 1998;41(4):416–423
- Prevalence of diabetic peripheral neuropathy and its relation to glycaemic control and potential risk factors: the EURODIAB IDDM Complications Study. Diabetologia. 1996;39(11):1377–1384
- Vascular risk factors and diabetic neuropathy. N Engl J Med. 2005;352(4):341–350
- . Effect of intensive therapy on the microvascular complications of type 1 diabetes mellitus. JAMA. 2002;287(19):2563–2569
- . Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: the Epidemiology of Diabetes Interventions and Complications (EDIC) Study. JAMA. 2003;290(16):2159–2167
- Cardiac autonomic dysfunction predicts cardiovascular mortality in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial. Diabetes. 2009;(suppl 1):58:A63
- Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Pract. 1995;28(2):103–117
- . Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33) (UK Prospective Diabetes Study (UKPDS) Group). Lancet. 1998;352(9131):837–853
- . Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34) (UK Prospective Diabetes Study (UKPDS) Group). Lancet. 1998;352(9131):854–865
- Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med. 2009;360(2):129–139
- . Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med. 2003;348(5):383–393
- . Influence of angiotensin converting enzyme inhibitor treatment on cardiac autonomic modulation in patients receiving haemodialysis. Nephrology (Carlton). 2006;11(6):497–501
- . Telmisartan in the treatment of hypertension in patients with chronic renal insufficiency. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2004;148(1):69–73
- . Determinants of heart rate variability in chronic hemodialysis patients. Am J Kidney Dis. 1998;31(4):602–606
- Reduction of sympathetic hyperactivity by enalapril in patients with chronic renal failure. N Engl J Med. 1999;340(17):1321–1328
- Sympathetic hyperactivity in hypertensive chronic kidney disease patients is reduced during standard treatment. Hypertension. 2007;49(3):506–510
- . Predictors of survival after cardiac arrest in outpatient hemodialysis clinics. Clin J Am Soc Nephrol. 2007;2(3):491–500
- Carvedilol increases two-year survival in dialysis patients with dilated cardiomyopathy: a prospective, placebo-controlled trial. J Am Coll Cardiol. 2003;41(9):1438–1444
- Beta-blocker prescription and outcomes in hemodialysis patients from the Japan Dialysis Outcomes and Practice Patterns Study. Nephron Clin Pract. 2009;113(3):c132–c139
- . Blood pressure and long-term mortality in United States hemodialysis patients: USRDS Waves 3 and 4 Study. Kidney Int. 2002;62(5):1784–1790
- . Autonomic neuropathy in hemodialysis patients treated with recombinant human erythropoietin. Int J Artif Organs. 1996;19(10):574–577
- . Beta blockers in the management of chronic kidney disease. Kidney Int. 2006;70(11):1905–1913
- . Effects on heart rate variability of metoprolol supplementary to ongoing ACE-inhibitor treatment in type I diabetic patients with abnormal albuminuria. Diabetologia. 2002;45(7):965–975
- . Decreased survival in diabetic patients with heart failure due to systolic dysfunction. Eur J Heart Fail. 2006;8(4):404–408
- Effect of propranolol on heart rate variability in patients with end-stage renal disease: a double-blind, placebo-controlled, randomized crossover pilot trial. Clin Nephrol. 2004;61(5):316–323
- . What type of beta-blocker should be used to treat chronic heart failure?. Circulation. 2000;102(5):484–486
- . Sympathetic overactivity and arterial hypertension in renal failure. Nephrol Dial Transplant. 2001;16(suppl 1):S67–S69
- The worsening of left ventricular hypertrophy is the strongest predictor of sudden cardiac death in haemodialysis patients: a 10 year survey. Nephrol Dial Transplant. 2004;19(7):1829–1834
- . Anemia with erythropoietin deficiency occurs early in diabetic nephropathy. Diabetes Care. 2001;24(3):495–499
- . Treatment of orthostatic hypotension with erythropoietin. N Engl J Med. 1993;329(9):611–615
- . Erythropoietin depletion and anaemia in diabetes mellitus. Diabet Med. 1999;16(10):813–819
- . Midodrine appears to be safe and effective for dialysis-induced hypotension: a systematic review. Nephrol Dial Transplant. 2004;19(10):2553–2558
- . Midodrine-induced vascular ischemia in a hemodialysis patient: a case report and literature review. Ren Fail. 2008;30(8):808–812
- Effect of sertraline hydrochloride on cardiac autonomic dysfunction in patients with hemodialysis-induced hypotension. Nephron Physiol. 2003;93(1):P21–P28
- . Effect of dialysis and renal transplantation on autonomic dysfunction in chronic renal failure. Kidney Int. 1991;40(3):489–495
- . Insulin in the acute renal adaptation to dietary phosphate restriction in the rat. Kidney Int. 1990;37(1):14–20
- . Predictors of haemodynamic instability and heart rate variability during haemodialysis. Nephrol Dial Transplant. 2004;19(8):2053–2060
- . Alteration of heart rate variability parameters in nondiabetic hemodialysis patients. Am J Nephrol. 2007;27(1):63–69
- Effects of different dialysis modalities on cardiac autonomic dysfunctions in end-stage renal disease patients: one year prospective study. Ren Fail. 2004;26(1):35–38
- . Blood pressure and heart rate variability in patients on conventional or sodium-profiling hemodialysis. Ren Fail. 2008;30(3):277–286
- Amitriptyline relieves diabetic neuropathy pain in patients with normal or depressed mood. Neurology. 1987;37(4):589–596
- . Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. N Engl J Med. 1992;326(19):1250–1256
- . The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms. Pain. 1990;42(2):135–144
- . Duloxetine vs. placebo in patients with painful diabetic neuropathy. Pain. 2005;116(1-2):109–118
- . Duloxetine for patients with diabetic peripheral neuropathic pain: a 6-month open-label safety study. Pain Med. 2006;7(5):373–385
- A randomized controlled trial of duloxetine in diabetic peripheral neuropathic pain. Neurology. 2006;67(8):1411–1420
- Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial. JAMA. 1998;280(21):1831–1836
- . Pregabalin for the treatment of painful diabetic peripheral neuropathy: a double-blind, placebo-controlled trial. Pain. 2004;110(3):628–638
- . Efficacy of pregabalin in neuropathic pain evaluated in a 12-week, randomised, double-blind, multicentre, placebo-controlled trial of flexible- and fixed-dose regimens. Pain. 2005;115(3):254–263
- . Relief of painful diabetic peripheral neuropathy with pregabalin: a randomized, placebo-controlled trial. J Pain. 2005;6(4):253–260
- Double-blind randomized trial of tramadol for the treatment of the pain of diabetic neuropathy. Neurology. 1998;50(6):1842–1846
- . Algorithm for neuropathic pain treatment: an evidence based proposal. Pain. 2005;118(3):289–305
- . Pharmacology and treatment of neuropathic pains. Curr Opin Neurol. 2009;22(5):467–474
- . Epidemiology, public health burden, and treatment of diabetic peripheral neuropathic pain: a review. Pain Med. 2007;8(suppl 2):S50–S62
- . Pregabalin for acute and chronic pain in adults. Cochrane Database Syst Rev. 2009;3:CD007076
- . Pharmacokinetics of pregabalin in subjects with various degrees of renal function. J Clin Pharmacol. 2003;43(3):277–283
- . Gabapentin dosing for neuropathic pain: evidence from randomized, placebo-controlled clinical trials. Clin Ther. 2003;25(1):81–104
- Disposition of gabapentin in anuric subjects on hemodialysis. J Clin Pharmacol. 1995;35(6):622–626
- . Gabapentin-induced myoclonus in end-stage renal disease. Epilepsia. 2005;46(1):156–158
- . Gabapentin toxicity: an important cause of altered consciousness in patients with uraemia. Emerg Med J. 2008;25(3):178–179
- . Gabapentin toxicity requiring intubation in a patient receiving long-term hemodialysis [letter]. Ann Intern Med. 2002;137(1):74
- . Antidepressants and anticonvulsants for diabetic neuropathy and postherpetic neuralgia: a quantitative systematic review. J Pain Symptom Manage. 2000;20(6):449–458
- . Antidepressant agents for the treatment of chronic pain and depression. Pharmacotherapy. 2007;27(11):1571–1587
- . Anticonvulsant drugs for acute and chronic pain. Cochrane Database Syst Rev. 2005;3:CD001133
- . Tramadol relieves pain and allodynia in polyneuropathy: a randomised, double-blind, controlled trial. Pain. 1999;83(1):85–90
- . Controlled-release oxycodone relieves neuropathic pain: a randomized controlled trial in painful diabetic neuropathy. Pain. 2003;105(1-2):71–78
- . Morphine, gabapentin, or their combination for neuropathic pain. N Engl J Med. 2005;352(13):1324–1334
- . Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial. Lancet. 2009;374(9697):1252–1261
- Effect of treatment with capsaicin on daily activities of patients with painful diabetic neuropathy (Capsaicin Study Group). Diabetes Care. 1992;15(2):159–165
- Botulinum toxin for diabetic neuropathic pain: a randomized double-blind crossover trial. Neurology. 2009;72(17):1473–1478
- . High-tone external muscle stimulation in end-stage renal disease: effects on symptomatic diabetic and uremic peripheral neuropathy. J Ren Nutr. 2008;18(1):46–51
Originally published online as doi: 10.1053/j.ajkd.2009.10.050 on December 31, 2009.
PII: S0272-6386(09)01448-6
doi: 10.1053/j.ajkd.2009.10.050
© 2010 National Kidney Foundation, Inc. Published by Elsevier Inc All rights reserved.
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Next »
American Journal of Kidney Diseases
Volume 55, Issue 2
, Pages 365-385
, February 2010
