American Journal of Kidney Diseases
Volume 55, Issue 3 , Pages 570-579 , March 2010

Dosing of Renal Replacement Therapy in Acute Kidney Injury: Lessons Learned From Clinical Trials

Received 10 February 2009 ,Accepted 10 November 2009.

References 

  1. Eknoyan G, Beck GJ, Cheung AK, et al. Effect of dialysis dose and membrane flux in maintenance hemodialysis. N Engl J Med. 2002;347(25):2010–2019
  2. Schiffl H, Lang SM, Fischer R. Daily hemodialysis and the outcome of acute renal failure. N Engl J Med. 2002;346(5):305–310
  3. Palevsky PM, Zhang JH, O'Connor TZ, et al. Intensity of renal support in critically ill patients with acute kidney injury. N Engl J Med. 2008;359(1):7–20
  4. Bellomo R. Do we know the optimal dose for renal replacement therapy in the intensive care unit?. Kidney Int. 2006;70(7):1202–1204
  5. Clark WR, Ronco C. Reconciling differences in effective solute removal between intermittent and continuous therapies. Semin Dial. 2001;14(4):289–293
  6. Casino FG, Lopez T. The equivalent renal urea clearance: a new parameter to assess dialysis dose. Nephrol Dial Transplant. 1996;11(8):1574–1581
  7. Gotch FA. The current place of urea kinetic modelling with respect to different dialysis modalities. Nephrol Dial Transplant. 11998;3(suppl 6):10-14.
  8. Ikizler TA, Sezer MT, Flakoll PJ, et al. Urea space and total body water measurements by stable isotopes in patients with acute renal failure. Kidney Int. 2004;65(2):725–732
  9. Casino FG, Marshall MR. Simple and accurate quantification of dialysis in acute renal failure patients during either urea non-steady state or treatment with irregular or continuous schedules. Nephrol Dial Transplant. 2004;19(6):1454–1466
  10. Evanson JA, Ikizler TA, Wingard R, et al. Measurement of the delivery of dialysis in acute renal failure. Kidney Int. 1999;55(4):1501–1508
  11. Ratanarat R, Permpikul C, Ronco C. Renal replacement therapy in acute renal failure: which index is best for dialysis dose quantification?. Int J Artif Organs. 2007;30(3):235–243
  12. Ronco C, Bellomo R, Homel P, et al. Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. Lancet. 2000;356(9223):26–30
  13. Troyanov S, Cardinal J, Geadah D, et al. Solute clearances during continuous venovenous haemofiltration at various ultrafiltration flow rates using Multiflow-100 and HF1000 filters. Nephrol Dial Transplant. 2003;18(5):961–966
  14. Hoke TS, Douglas IS, Klein CL, et al. Acute renal failure after bilateral nephrectomy is associated with cytokine-mediated pulmonary injury. J Am Soc Nephrol. 2007;18(1):155–164
  15. Liu M, Liang Y, Chigurupati S, et al. Acute kidney injury leads to inflammation and functional changes in the brain. J Am Soc Nephrol. 2008;19(7):1360–1370
  16. Wiesen PN, Monchi M, Dubois BE, Preiser JCE, Damas PP. Cascade high volume hemofiltration: preliminary data in septic shock patients. Blood Purif. 2007;25:190;(abstract 14)
  17. Morgera S, Slowinski T, Melzer C, et al. Renal replacement therapy with high-cutoff hemofilters: impact of convection and diffusion on cytokine clearances and protein status. Am J Kidney Dis. 2004;43(3):444–453
  18. Honoré PM, Joannes-Boyau O, Gressens B. Blood and plasma treatments: the rationale of high-volume hemofiltration. Contrib Nephrol. 2007;156:387–395
  19. Di Carlo JV, Alexander SR. Hemofiltration for cytokine-driven illnesses: the mediator delivery hypothesis. Int J Artif Organs. 2005;28(8):777–786
  20. Goldstein SL, Somers MJ, Baum MA, et al. Pediatric patients with multi-organ dysfunction syndrome receiving continuous renal replacement therapy. Kidney Int. 2005;67(2):653–658
  21. Goldstein SL, Currier H, Graf C, Cosio CC, Brewer ED, Sachdeva R. Outcome in children receiving continuous venovenous hemofiltration. Pediatrics. 2001;107(6):1309–1312
  22. Gillespie RS, Seidel K, Symons JM. Effect of fluid overload and dose of replacement fluid on survival in hemofiltration. Pediatr Nephrol. 2004;19(12):1394–1399
  23. Foland JA, Fortenberry JD, Warshaw BL, et al. Fluid overload before continuous hemofiltration and survival in critically ill children: a retrospective analysis. Crit Care Med. 2004;32(8):1771–1776
  24. Lane PH, Mauer SM, Blazar BR, Ramsay NK, Kashtan CE. Outcome of dialysis for acute renal failure in pediatric bone marrow transplant patients. Bone Marrow Transplant. 1994;13(5):613–617
  25. Payen D, de Pont AC, Sakr Y, Spies C, Reinhart K, Vincent JL. A positive fluid balance is associated with a worse outcome in patients with acute renal failure. Crit Care. 2008;12(3):R74
  26. Bouchard J, Soroko SB, Chertow GM, et al. Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury. Kidney Int. 2009;76(4):422–427
  27. Bouman CS, Oudemans-Van Straaten HM, Tijssen JG, Zandstra DF, Kesecioglu J. Effects of early high-volume continuous venovenous hemofiltration on survival and recovery of renal function in intensive care patients with acute renal failure: a prospective, randomized trial. Crit Care Med. 2002;30(10):2205–2211
  28. Saudan P, Niederberger M, De Seigneux S, et al. Adding a dialysis dose to continuous hemofiltration increases survival in patients with acute renal failure. Kidney Int. 2006;70(7):1312–1317
  29. Tolwani AJ, Campbell RC, Stofan BS, Lai KR, Oster RA, Wille KM. Standard versus high-dose CVVHDF for ICU-related acute renal failure. J Am Soc Nephrol. 2008;19(6):1233–1238
  30. Bellomo R, Cass A, Cole L, et al. Intensity of continous renal replacement therapy in critically ill patients. N Engl J Med. 2009;361(17):1627–1638
  31. Palevsky P, Zhang JH, O'Connor TZ. Renal support in critically ill patients with acute kidney injury. N Engl J Med. 2008;359(18):1961–1962
  32. Faulhaber-Walter R, Hafer C, Jahr N, et al. The Hannover Dialysis Outcome study: comparison of standard versus intensified extended dialysis for treatment of patients with acute kidney injury in the intensive care unit. Nephrol Dial Transplant. 2009;24(7):2179–2186
  33. Tolwani AJ, Speer R, Stofan B, Lai KR, Wille KM. A randomized prospective study comparing high dose continuous venovenous hemodiafiltration (CVVHDF) to standard dose CVVHDF in critically ill patients with acute kidney injury. Blood Purif. 2007;25:193;(abstract 22)
  34. Liu KD, Himmelfarb J, Paganini E, et al. Timing of initiation of dialysis in critically ill patients with acute kidney injury. Clin J Am Soc Nephrol. 2006;1(5):915–919
  35. Uchino S, Fealy N, Baldwin I, Morimatsu H, Bellomo R. Pre-dilution vs. post-dilution during continuous veno-venous hemofiltration: impact on filter life and azotemic control. Nephron Clin Pract. 2003;94(4):c94–c98
  36. Palevsky PM, O'Connor T, Zhang JH, Star RA, Smith MW. Design of the VA/NIH Acute Renal Failure Trial Network (ATN) Study: intensive versus conventional renal support in acute renal failure. Clin Trials. 2005;2(5):423–435
  37. Gabriel DP, Caramori JT, Martim LC, Barretti P, Balbi AL. High volume peritoneal dialysis vs daily hemodialysis: a randomized, controlled trial in patients with acute kidney injury. Kidney Int Suppl. 2008;108:S87–S93
  38. Overberger P, Pesacreta M, Palevsky PM. Management of renal replacement therapy in acute kidney injury: a survey of practitioner prescribing practices. Clin J Am Soc Nephrol. 2007;2(4):623–630
  39. Chan CT, Floras JS, Miller JA, Richardson RM, Pierratos A. Regression of left ventricular hypertrophy after conversion to nocturnal hemodialysis. Kidney Int. 2002;61(6):2235–2239
  40. Mucsi I, Hercz G, Uldall R, Ouwendyk M, Francoeur R, Pierratos A. Control of serum phosphate without any phosphate binders in patients treated with nocturnal hemodialysis. Kidney Int. 1998;53(5):1399–1404
  41. Tumlin J, Wali R, Williams W, et al. Efficacy and safety of renal tubule cell therapy for acute renal failure. J Am Soc Nephrol. 2008;19(5):1034–1040
  42. Humes HD, Dillon JJ, Tolwani A, et al. A novel selective cytopheretic inhibitory device (SCD) improves mortality in ICU patients with acute kidney injury (AKI) and multiorgan failure (MOF) in a phase II clinical study [abstract]. J Am Soc Nephrol. 2008;19:458A

 Originally published online as doi:10.1053/j.ajkd.2009.11.007 on February 1, 2010.

PII: S0272-6386(09)01563-7

doi: 10.1053/j.ajkd.2009.11.007

American Journal of Kidney Diseases
Volume 55, Issue 3 , Pages 570-579 , March 2010

Article Tools