American Journal of Kidney Diseases
Volume 56, Issue 1 , Pages e1-e4 , July 2010

Hemolysis in a Patient With Alkaptonuria and Chronic Kidney Failure

  • Anne-Elisabeth Heng, MD

      Affiliations

    • Service de Néphrologie Réanimation Médicale, Pole REUNNIRH, Clermont-Ferrand, France
    • Corresponding Author InformationAddress correspondence to Anne-Elisabeth Heng, MD, CHU Clermont-Ferrand, Service de Néphrologie Réanimation Médicale, Hôp G Montpied, F63003 Clermont-Ferrand, France
    • ,
  • Marie Courbebaisse, MD

      Affiliations

    • Service de Néphrologie Réanimation Médicale, Pole REUNNIRH, Clermont-Ferrand, France
    • ,
  • Jean Louis Kemeny, MD

      Affiliations

    • Service de Pathologie Médicale, CHU Clermont-Ferrand, Hôpital Gabriel Montpied, Clermont-Ferrand, France
    • UFR Médecine, Univ Clermont 1, Clermont-Ferrand, France
    • ,
  • Raluca Matesan, MD

      Affiliations

    • Service de Néphrologie Réanimation Médicale, Pole REUNNIRH, Clermont-Ferrand, France
    • ,
  • Claude Bonniol, MD

      Affiliations

    • Service de Néphrologie Réanimation Médicale, Pole REUNNIRH, Clermont-Ferrand, France
    • ,
  • Patrice Deteix, MD

      Affiliations

    • Service de Néphrologie Réanimation Médicale, Pole REUNNIRH, Clermont-Ferrand, France
    • UFR Médecine, Univ Clermont 1, Clermont-Ferrand, France
    • ,
  • Bertrand Souweine, MD

      Affiliations

    • Service de Néphrologie Réanimation Médicale, Pole REUNNIRH, Clermont-Ferrand, France
    • UFR Médecine, Univ Clermont 1, Clermont-Ferrand, France

Received 14 August 2009 ,Accepted 25 November 2009.

References 

  1. Phornphutkul C, Introne WJ, Perry MB, et al. Natural history of alkaptonuria. N Engl J Med. 2002;347(26):2111–2121
  2. Venkataseshan VS, Chandra B, Graziano V, et al. Alkaptonuria and renal failure: a case report and review of the literature. Mod Pathol. 1992;5(4):464–471
  3. Kazancioglu R, Taylan I, Aksak F, et al. Alkaptonuria and renal failure: a case report. J Nephrol. 2004;17(3):441–445
  4. Zatkova A, de Bernabe DB, Polakova H, et al. High frequency of alkaptonuria in Slovakia (Evidence for the appearance of multiple mutations in HGO involving different mutational hot spots). Am J Hum Genet. 2000;67(5):1333–1339
  5. Ladjouze-Rezig A, Rodriguez de Cordoba S, Aquaron R. Ochronotic rheumatism in Algeria: clinical, radiological, biological and molecular studies—a case study of 14 patients in 11 families. Joint Bone Spine. 2006;73(3):284–292
  6. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31–41
  7. Introne WJ, Phornphutkul C, Bernardini I, McLaughlin K, Fitzpatrick D, Gahl WA. Exacerbation of the ochronosis of alkaptonuria due to renal insufficiency and improvement after renal transplantation. Mol Genet Metab. 2002;77(1-2):136–142
  8. Hegedus ZL, Nayak U. Homogentisic acid and structurally related compounds as intermediates in plasma soluble melanin formation and in tissue toxicities. Arch Int Physiol Biochim Biophys. 1994;102(3):175–181
  9. Hegedus ZL. The probable involvement of soluble and deposited melanins, their intermediates and the reactive oxygen side-products in human diseases and aging. Toxicology. 2000;145(2-3):85–101
  10. Kuroda M, Asaka S, Tofuku Y, Takeda R. Serum antioxidant activity in uremic patients. Nephron. 1985;41(3):293–298
  11. Forslind K, Wollheim FA, Akesson B, Rydholm U. Alkaptonuria and ochronosis in three siblings (Ascorbic acid treatment monitored by urinary HGA excretion). Clin Exp Rheumatol. 1988;6(3):289–292
  12. Suwannarat P, O'Brien K, Perry MB, et al. Use of nitisinone in patients with alkaptonuria. Metabolism. 2005;54(6):719–728

 Originally published online as doi:10.1053/j.ajkd.2009.11.023 on March 8, 2010.

PII: S0272-6386(09)01656-4

doi: 10.1053/j.ajkd.2009.11.023

American Journal of Kidney Diseases
Volume 56, Issue 1 , Pages e1-e4 , July 2010

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