American Journal of Kidney Diseases
Volume 56, Issue 3 , Pages 547-557 , September 2010

Barriers to Adult Hemodialysis Patients' Self-Management of Oral Medications

  • Teri Browne, PhD

      Affiliations

    • University of South Carolina, Columbia, SC
    • Corresponding Author InformationAddress correspondence to Teri Browne, PhD, University of South Carolina College of Social Work, Desaussure 130, Columbia, SC 29208
    • ,
  • Joseph R. Merighi, PhD

      Affiliations

    • Boston University, Boston, MA

Received 21 October 2009 ,Accepted 1 March 2010.

References 

  1. Manley HJ, Garvin CG, Drayer DK, et al. Medication prescribing patterns in ambulatory haemodialysis patients: comparisons of USRDS to a large not-for-profit dialysis provider. Nephrol Dial Transplant. 2004;19(7):1842–1848
  2. Chiu Y-W, Teitelbaum I, Misra M, de Leon EM, Adzize T, Mehrotra R. Pill burden, adherence, hyperphosphatemia, and quality of life in maintenance dialysis patients. Clin J Am Soc Nephrol. 2009;4(6):1089–1096
  3. Sabate E. (WHO/NMH/CCH). Adherence to Long-Term Therapies: Policy for Action. June 4-5, 2001.
  4. Eknoyan G, Levin A, Levin NW. Bone metabolism and disease in chronic kidney disease. Am J Kidney Dis. 2003;42:1–201
  5. Craver L, Marco MP, Martínez I, et al. Mineral metabolism parameters throughout chronic kidney disease stages 1-5—achievement of K/DOQI target ranges. Nephrol Dial Transplant. 2007;22(4):1171–1176
  6. Levin A, Bakris GL, Molitch M, et al. Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease. Kidney Int. 2007;71(1):31–38
  7. Rozen-Zvi B, Gafter-Gvili A, Paul M, Leibovici L, Shpilberg O, Gafter U. Intravenous versus oral iron supplementation for the treatment of anemia in CKD: systematic review and meta-analysis. Am J Kidney Dis. 2008;52(5):897–906
  8. Strippoli GFM, Tong A, Palmer SC, Elder G, Craig JC. Calcimimetics for secondary hyperparathyroidism in chronic kidney disease patients. Cochrane Database Syst Rev. 2006;4:CD006254
  9. Strippoli GFM, Navaneethan SD, Johnson DW, et al. Effects of statins in patients with chronic kidney disease: meta-analysis and meta-regression of randomised controlled trials. BMJ. 2008;336(7645):645–651
  10. Federal Register. Conditions for coverage for ESRD facilities: 42 CFR Part 494. April 2008;
  11. Glasgow NJ, Jeon Y-H, Kraus SG, Pearce-Brown CL. Chronic disease self-management support: the way forward for Australia. Med J Aust. 2008;189(10 suppl):S14–S16
  12. Lindberg M, Lindberg P. Overcoming obstacles for adherence to phosphate binding medication in dialysis patients: a qualitative study. Pharm World Sci. 2008;30(5):571–576
  13. Barlow J, Wright C, Sheasby J, Turner A, Hainsworth J. Self-management approaches for people with chronic conditions: a review. Patient Educ Counsel. 2002;48(2):177–187
  14. Wagner EH. Chronic disease management: what will it take to improve care for chronic illness?. Eff Clin Pract. 1998;1(1):2–4
  15. New England Healthcare Institute. Thinking Outside the Pillbox: A System-Wide Approach to Improving Patient Medication Adherence for Chronic Disease. Cambridge, MA: New England Healthcare Institute; 2009;
  16. Alt PS, Schatell D. How to make the new conditions for coverage work in your dialysis clinic: teaching self-management: new conditions emphasize patient participation in care. Nephrol News Issues. 2009;23(7):36;38, 40-41
  17. Hutchison AJ, Laville M. Switching to lanthanum carbonate monotherapy provides effective phosphate control with a low tablet burden. Nephrol Dial Transplant. 2008;23(11):3677–3684
  18. Evans RW, Manninen DL, Garrison LP, et al. The quality of life of patients with end-stage renal disease. N Engl J Med. 1985;312(9):553–559
  19. Mapes DL, Lopes AA, Satayathum S, et al. Health-related quality of life as a predictor of mortality and hospitalization: the Dialysis Outcomes and Practice Patterns Study (DOPPS). Kidney Int. 2003;64(1):339–349
  20. Knight EL, Ofsthun N, Teng M, Lazarus JM, Curhan GC. The association between mental health, physical function, and hemodialysis mortality. Kidney Int. 2003;63(5):1843–1851
  21. Odegard PS, Capoccia K. Medication taking and diabetes: a systematic review of the literature. Diabetes Educ. 2007;33(6):1014–1029
  22. Odegard PS, Gray SL. Barriers to medication adherence in poorly controlled diabetes mellitus. Diabetes Educ. 2008;34(4):692–697
  23. Iskedjian M, Einarson TR, MacKeigan LD, et al. Relationship between daily dose frequency and adherence to antihypertensive pharmacotherapy: Evidence from a meta-analysis. Clin Ther. 2002;24(2):302–316
  24. Walker EA, Molitch M, Kramer MK, et al. Adherence to preventive medications: predictors and outcomes in the Diabetes Prevention Program. Diabetes Care. 2006;29(9):1997–2002
  25. Ryan GW, Wagner GJ. Pill taking 'routinization': a critical factor to understanding episodic medication adherence. AIDS Care. 2003;15(6):795–806
  26. Fransen GAJ, Mesters I, Janssen MJR, Knottnerus JA, Muris JWM. Which patient-related factors determine self-perceived patient adherence to prescribed dyspepsia medication?. Health Educ Res. 2009;24(5):788–798
  27. Cleary DJ, Matzke GR, Alexander AC, Joy MS. Medication knowledge and compliance among patients receiving long-term dialysis. Am J Health Syst Pharm. 1995;52(17):1895–1900
  28. Sleath BL, Krishnadas R, Cho M, et al. Patient-reported barriers to glaucoma medication access, use, and adherence in southern India. Indian J Ophthalmol. 2009;57(1):63–68
  29. Trinacty CM, Adams AS, Soumerai SB, et al. Racial differences in long-term adherence to oral antidiabetic drug therapy: a longitudinal cohort study. BMC Health Serv Res. 2009;9:24
  30. Kalichman SC, Ramachandran B, Catz S. Adherence to combination antiretroviral therapies in HIV patients of low health literacy. J Gen Intern Med. 1999;14(5):267–273
  31. Franks P, Gold MR, Fiscella K. Sociodemographics, self-rated health, and mortality in the US. Soc Sci Med. 2003;56(12):2505–2514
  32. Elliott RA. Poor adherence to medication in adults with rheumatoid arthritis: reasons and solutions. Dis Manag Health Outcomes. 2008;16(1):13–29
  33. Curtin RB, Svarstad BL, Keller TH. Hemodialysis patients' noncompliance with oral medications. ANNA J. 1999;26(3):307–316
  34. Bame SI, Petersen N, Wray NP. Variation in hemodialysis patient compliance according to demographic characteristics. Soc Sci Med. 1993;37(8):1035–1043
  35. Schectman JM, Nadkarni MM, Voss JD. The association between diabetes metabolic control and drug adherence in an indigent population. Diabetes Care. 2002;25(6):1015–1021
  36. Saran R, Bragg-Gresham JL, Rayner HC, et al. Nonadherence in hemodialysis: associations with mortality, hospitalization, and practice patterns in the DOPPS. Kidney Int. 2003;64(1):254–262
  37. Karamanidou C, Clatworthy J, Weinman J, Horne R. A systematic review of the prevalence and determinants of nonadherence to phosphate binding medication in patients with end-stage renal disease. BMC Nephrol. 2008;9:2
  38. Holley JL, DeVore CC. Why all prescribed medications are not taken: results from a survey of chronic dialysis patients. Adv Perit Dial. 2006;22:162–166
  39. Ross S, Walker A, MacLeod MJ. Patient compliance in hypertension: role of illness perceptions and treatment beliefs. J Hum Hypertens. 2004;18(9):607–613
  40. Raiz LR, Kilty KM, Henry ML, Ferguson RM. Medication compliance following renal transplantation. Transplantation. 1999;68(1):51–55
  41. DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med. 2000;160(14):2101–2107
  42. Kutner NG, Zhang R, McClellan WM, Cole SA. Psychosocial predictors of non-compliance in haemodialysis and peritoneal dialysis patients. Nephrol Dial Transplant. 2002;17(1):93–99
  43. Golin CE, Liu H, Hays RD, et al. A prospective study of predictors of adherence to combination antiretroviral medication. J Gen Intern Med. 2002;17(10):756–765
  44. Nabi H, Vahtera J, Singh-Manoux A, et al. Do psychological attributes matter for adherence to antihypertensive medication? (The Finnish Public Sector Cohort Study). J Hypertens. 2008;26(11):2236–2243
  45. Leserman J, Ironson G, O'Cleirigh C, Fordiani JM, Balbin E. Stressful life events and adherence in HIV. AIDS Patient Care STDs. 2008;22(5):403–411
  46. Andrus MR, Roth MT. Health literacy: a review. Pharmacotherapy. 2002;22(3):282–302
  47. Speros C. Health literacy: concept analysis. J Adv Nurs. 2005;50(6):633–640
  48. Bass L. Health literacy: implications for teaching the adult patient. J Infus Nurs. 2005;28(1):15–22
  49. Kantor A. A new level of understanding (Health insurers are developing health literacy initiatives and taking steps to help consumers get clear information). AHIP Cover. 2006;47(6):18–22
  50. Williams MV, Parker RM, Baker DW, et al. Inadequate functional health literacy among patients at two public hospitals. JAMA. 1995;274(21):1677–1682
  51. Grubbs V, Gregorich SE, Perez-Stable EJ, Hsu C-Y. Health literacy and access to kidney transplantation. Clin J Am Soc Nephrol. 2009;4(1):195–200
  52. Leggat JE, Orzol SM, Hulbert-Shearon TE, et al. Noncompliance in hemodialysis: predictors and survival analysis. Am J Kidney Dis. 1998;32(1):139–145
  53. Devraj R, Gordon EJ. Health literacy and kidney disease: toward a new line of research. Am J Kidney Dis. 2009;53(5):884–889
  54. Kim SS, Kaplowitz S, Johnston MV. The effects of physician empathy on patient satisfaction and compliance. Eval Health Prof. 2004;27(3):237–251
  55. Marple BF, Fornadley JA, Patel AA, et al. Keys to successful management of patients with allergic rhinitis: focus on patient confidence, compliance, and satisfaction. Otolaryngol Head Neck Surg. 2007;136(6 suppl):S107–S124
  56. Hawkshead J, Krousel-Wood MA. Techniques for measuring medication adherence in hypertensive patients in outpatient settings: advantages and limitations. Dis Manag Health Outcomes. 2007;15(2):109–118
  57. Kammerer J, Garry G, Hartigan M, Carter B, Erlich L. Adherence in patients on dialysis: strategies for success. Nephrol Nurs J. 2007;34(5):479–486
  58. Anderson JG, Bartkus DE. Choice of medical care: a behavioral model of health and illness behavior. J Health Soc Behav. 1973;14(4):348–362
  59. Janz NK, Becker MH. The health belief model: a decade later. Health Educ Q. 1984;11(1):1–47
  60. Hekler EB, Lambert J, Leventhal E, Leventhal H, Jahn E, Contrada RJ. Commonsense illness beliefs, adherence behaviors, and hypertension control among African Americans. J Behav Med. 2008;31(5):391–400
  61. Leventhal H, Weinman J, Leventhal EA, Phillips LA. Health psychology: the search for pathways between behavior and health. Ann Rev Psychol. 2008;59(1):477–505
  62. Loghman-Adham M. Medication noncompliance in patients with chronic disease: issues in dialysis and renal transplantation. Am J Manag Care. 2003;9(2):155–171
  63. Curtin RB, Walters BAJ, Schatell D, Pennell P, Wise M, Klicko K. Self-efficacy and self-management behaviors in patients with chronic kidney disease. Adv Chronic Kidney Dis. 2008;15(2):191–205
  64. Fogarty JS, Youngs GA. Psychological reactance as a factor in patient noncompliance with medication taking: a field experiment. J Appl Soc Psychol. 2000;30(11):2365–2391
  65. Jones DL, McPherson-Baker S, Lydston D, et al. Efficacy of a group medication adherence intervention among HIV positive women: the SMART/EST Women's Project. AIDS Behav. 2007;11(1):79–86
  66. Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005;353(5):487–497
  67. Ruddy K, Mayer E, Partridge A. Patient adherence and persistence with oral anticancer treatment. CA Cancer J Clin. 2009;59(1):56–66
  68. Fischer D, Cline K, Plone MA, Dillon M, Burke SK, Blair AT. Results of a randomized crossover study comparing once-daily and thrice-daily sevelamer dosing. Am J Kidney Dis. 2006;48(3):437–444
  69. Reginster JY, Rabenda V, Neuprez A. Adherence, patient preference and dosing frequency: understanding the relationship. Bone. 2006;38(4 suppl 1):S2–S6
  70. Summer L, Nemore P, Finberg J. Improving the Medicare Part D Program for the Most Vulnerable Beneficiaries. New York, NY: Commonwealth Fund; 2007;
  71. US Department of Health and Human Services. Patient Self-Management Support Programs: An Evaluation. AHRQ Publication No. 08-0011 Rockville, MD: AHRQ; 2007;
  72. Bodenheimer T, Lorig K, Holman H, Grumbach K. Patient self-management of chronic disease in primary care. JAMA. 2002;288(19):2469–2475
  73. Thomas-Hawkins C, Zazworsky D. Self-management of chronic kidney disease. Am J Nurs. 2005;105(10):40–48
  74. Healthy People 2010. Understanding and Improving Health: Office of Disease Prevention and Health Promotion. Washington, DC: Department of Health and Human Services; 2009;
  75. Kripalani S, Henderson LE, Chiu EY, Robertson R, Kolm P, Jacobson TA. Predictors of medication self-management skill in a low-literacy population. J Gen Intern Med. 2006;21(8):852–856
  76. Riekert KA, Drotar D. The beliefs about medication scale: development, reliability, and validity. J Clin Psychol Med Settings. 2002;9(2):177–184
  77. Horne R, Weinman J, Hankins M. The Beliefs About Medicines Questionnaire: the development and evaluation of a new method for assessing the cognitive representation of medication. Psychol Health. 1999;14(1):1–24
  78. Karamanidou C, Weinman J, Horne R. Improving haemodialysis patients' understanding of phosphate-binding medication: a pilot study of a psycho-educational intervention designed to change patients' perceptions of the problem and treatment. Br J Health Psychol. 2008;13(pt 2):205–214
  79. Halm EA, Mora P, Leventhal H. No symptoms, no asthma: the acute episodic disease belief is associated with poor self-management among inner-city adults with persistent asthma. Chest. 2006;129(3):573–580
  80. Block GA, Klassen PS, Lazarus JM, Ofsthun N, Lowrie EG, Chertow GM. Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J Am Soc Nephrol. 2004;15(8):2208–2218
  81. Kestenbaum B, Belozeroff V. Mineral metabolism disturbances in patients with chronic kidney disease. Eur J Clin Invest. 2007;37(8):607–622
  82. Moe S, Drüeke T, Cunningham J, et al. Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 2006;69(11):1945–1953
  83. Kalantar-Zadeh K, Kuwae N, Regidor DL, et al. Survival predictability of time-varying indicators of bone disease in maintenance hemodialysis patients. Kidney Int. 2006;70(4):771–780

 Originally published online as doi:10.1053/j.ajkd.2010.03.002 on April 29, 2010.

PII: S0272-6386(10)00585-8

doi: 10.1053/j.ajkd.2010.03.002

American Journal of Kidney Diseases
Volume 56, Issue 3 , Pages 547-557 , September 2010

Article Tools

* Image Usage & Resolution