American Journal of Kidney Diseases
Volume 56, Issue 3 , Pages 513-521 , September 2010

Lower Retinol Levels as an Independent Predictor of Mortality in Long-term Hemodialysis Patients: A Prospective Observational Cohort Study

  • Marta Kalousová, MD, PhD

      Affiliations

    • Institute of Clinical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague, General University Hospital in Prague, Czech Republic
    • Corresponding Author InformationAddress correspondence to Marta Kalousová, MD, PhD, Institute of Clinical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic, Na Bojišti 3, 121 08 Prague 2, Czech Republic
    • ,
  • Aleš A. Kuběna, MSc

      Affiliations

    • Institute of Clinical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague, General University Hospital in Prague, Czech Republic
    • ,
  • Milada Koštířová, MSc

      Affiliations

    • Institute of Clinical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague, General University Hospital in Prague, Czech Republic
    • ,
  • Marie Vinglerová, MSc

      Affiliations

    • Institute of Clinical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague, General University Hospital in Prague, Czech Republic
    • ,
  • Oto Mestek Ing, PhD

      Affiliations

    • Institute of Chemical Technology, Prague, Czech Republic
    • ,
  • Sylvie Dusilová-Sulková, MD, DSc

      Affiliations

    • Institute of Clinical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague, General University Hospital in Prague, Czech Republic
    • ,
  • Vladimír Tesař, MD, DSc

      Affiliations

    • Department of Nephrology, First Faculty of Medicine, Charles University in Prague, General University Hospital in Prague, Czech Republic
    • ,
  • Tomáš Zima, MD, DSc

      Affiliations

    • Institute of Clinical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague, General University Hospital in Prague, Czech Republic

Received 22 October 2009 ,Accepted 25 March 2010.

References 

  1. Foley RN, Parfrey PS, Sarnak MJ. Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis. 1998;32(5 suppl 3):S112–S119
  2. Locatelli F, Canaud B, Eckardt KU, Stenvinkel P, Wanner C, Zoccali C. Oxidative stress in end-stage renal disease: an emerging threat to patient outcome. Nephrol Dial Transplant. 2003;18(7):1272–1280
  3. Himmelfarb J. Oxidative stress in hemodialysis. Contrib Nephrol. 2008;161:132–137
  4. Stenvinkel P, Carrero JJ, Axelsson J, Lindholm B, Heimbürger O, Massy Z. Emerging biomarkers for evaluating cardiovascular risk in the chronic kidney disease patient: how do new pieces fit into the uremic puzzle?. Clin J Am Soc Nephrol. 2008;3(2):505–521
  5. Mora JR, Iwata M, von Andrian UH. Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol. 2008;8:685–698
  6. Shrimali RK, Irons RD, Carlson BA, et al. Selenoproteins mediate T cell immunity through an antioxidant mechanism. J Biol Chem. 2008;283(29):20181–20185
  7. Hirano T, Murakami M, Fukada T, Nishida K, Yamasaki S, Suzuki T. Roles of zinc and zinc signaling in immunity: zinc as an intracellular signaling molecule. Adv Immunol. 2008;97:149–176
  8. Maggini S, Wintergerst ES, Beveridge S, Hornig DH. Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses. Br J Nutr. 2007;98(suppl 1):S29–S35
  9. Connolly GM, Cunningham R, Maxwell AP, Young IS. Decreased serum retinol is associated with increased mortality in renal transplant recipients. Clin Chem. 2007;53(10):1841–1846
  10. Kalantar-Zadeh K, Kopple JD. Trace elements and vitamins in maintenance dialysis patients. Adv Ren Replace Ther. 2003;10(3):170–182
  11. Cundy T, Earnshaw M, Heynen G, Kanis JA. Vitamin A and hyperparathyroid bone disease in uremia. Am J Clin Nutr. 1983;38(6):914–920
  12. Zima T, Janebová M, Nemecek K, Bártová V. Retinol and alpha-tocopherol in hemodialysis patients. Ren Fail. 1998;20(3):505–512
  13. Ziegelmeier M, Bachmann A, Seeger J, et al. Serum levels of adipokine retinol-binding protein-4 in relation to renal function. Diabetes Care. 2007;30(10):2588–2592
  14. Frey SK, Nagl B, Henze A, et al. Isoforms of retinol binding protein 4 (RBP4) are increased in chronic diseases of the kidney but not of the liver. Lipids Health Dis. 2008;7:29
  15. Dakshinamurty KV, Rao PV, Saibaba KS, et al. Oxidative stress in hemodialysis—postdialytic changes. Clin Lab. 2003;49(5-6):255–261
  16. Bonnefont-Rousselot D, Lehmann E, Jaudon MC, Delattre J, Perrone B, Rechke JP. Blood oxidative stress and lipoperoxidation oxidizability in haemodialysis patients: effect of the use of a vitamin E-coated dialysis membrane. Nephrol Dial Transplant. 2000;15(12):2020–2028
  17. Kaminska-Galwa B, Grzeszczak W, Jedryczko A, Pachelski J. Influence of long-term hemodialysis on serum trace elements concentration in patients with chronic renal failure. Przegl Lek. 1994;51(1):9–14
  18. Krachler M, Scharfetter H, Wirnsberger GH. Kinetics of metal cations magnesium, calcium, copper, strontium, and lead in chronic hemodialysis patients. Clin Nephrol. 2000;54(1):35–44
  19. Srinivasa Rao PV, Dakshinamurty KV, Saibaba KS, et al. Oxidative stress in hemodialysis—intradialysic changes. Redox Rep. 2001;6(5):303–309
  20. Kalantar-Zadeh K, Block G, Humphreys MH, Kopple JD. Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients. Kidney Int. 2003;63(3):793–808
  21. Xu Q, Lucio-Cazana J, Kitamura M, Ruan X, Fine LG, Norman JT. Retinoids in nephrology: promises and pitfalls. Kidney Int. 2004;66(6):2119–2131
  22. Choudhary R, Palm-Leis A, Scott RC, et al. All-trans retinoic acid prevents development of cardiac remodeling in aortic banded rats by inhibiting the renin-angiotensin system. Am J Physiol Heart Circ Physiol. 2008;294(2):H633–H644
  23. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev. 2008;2:CD007176
  24. Miller ER, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005;142(1):37–46
  25. Berry D, Wathen JK, Newell M. Bayesian model averaging in meta-analysis: vitamin E supplementation and mortality. Clin Trials. 2009;6(1):28–41
  26. Sommer A, Tarwotjo I, Djunaedi E, et al. Impact of vitamin A supplementation on childhood mortality (A randomised controlled community trial). Lancet. 1986;1(8491):1169–1173
  27. Rahmathullah L, Underwood BA, Thulasiraj RD, et al. Reduced mortality among children in southern India receiving a small weekly dose of vitamin A. N Engl J Med. 1990;323(14):929–935

 Originally published online as doi:10.1053/j.ajkd.2010.03.031 on June 14, 2010.

PII: S0272-6386(10)00831-0

doi: 10.1053/j.ajkd.2010.03.031

American Journal of Kidney Diseases
Volume 56, Issue 3 , Pages 513-521 , September 2010

Article Tools

* Image Usage & Resolution