American Journal of Kidney Diseases
Volume 56, Issue 3 , Pages 540-546 , September 2010

Analytical and Biological Variation in Measures of Anemia and Iron Status in Patients Treated With Maintenance Hemodialysis

  • David B. Van Wyck, MD

      Affiliations

    • Office of the Chief Medical Officer, DaVita Inc, Denver, CO
    • Corresponding Author InformationAddress correspondence to David B. Van Wyck, MD, DaVita Inc, 601 Hawaii St, El Segundo, CA 90245
    • ,
  • Harry Alcorn Jr, PharmD

      Affiliations

    • DaVita Clinical Research Inc, Minneapolis, MN
    • ,
  • Resmi Gupta, MS

      Affiliations

    • Vital Systems Inc, Schaumburg, IL

Received 23 November 2009 ,Accepted 5 May 2010.

References 

  1. Lacson E, Ofsthun N, Lazarus JM. Effect of variability in anemia management on hemoglobin outcomes in ESRD. Am J Kidney Dis. 2003;41(1):111–124
  2. Fishbane S, Berns JS. Hemoglobin cycling in hemodialysis patients treated with recombinant human erythropoietin. Kidney Int. 2005;68(3):1337–1343
  3. Berns JS, Elzein H, Lynn RI, Fishbane S, Meisels IS, Deoreo PB. Hemoglobin variability in epoetin-treated hemodialysis patients. Kidney Int. 2003;64(4):1514–1521
  4. Spiegel DM. Hemoglobin variability in chronic kidney disease: a cross-sectional study. Am J Med Sci. 2009;337(5):340–343
  5. Boudville NC, Djurdjev O, Macdougall IC, et al. Hemoglobin variability in nondialysis chronic kidney disease: examining the association with mortality. Clin J Am Soc Nephrol. 2009;4(7):1176–1182
  6. Casale G, Migliavacca A, Bonora C, Zurita IE, de Nicola P. Circadian rhythm of plasma iron, total iron binding capacity and serum ferritin in arteriosclerotic aged patients. Age Ageing. 1981;10(2):115–118
  7. Dale JC, Burritt MF, Zinsmeister AR. Diurnal variation of serum iron, iron-binding capacity, transferrin saturation, and ferritin levels. Am J Clin Pathol. 2002;117(5):802–808
  8. Belza A, Ersboll AK, Henriksen M, Thilsted SH, Tetens I. Day-to-day variation in iron-status measures in young iron-deplete women. Br J Nutr. 2005;94(4):551–556
  9. Fraser CG. Biological Variation: From Principles to Practise. Washington DC: AACC Press; 2001;
  10. Basiotis PP, Welsh SO, Cronin FJ, Kelsay JL, Mertz W. Number of days of food intake records required to estimate individual and group nutrient intakes with defined confidence. J Nutr. 1987;117(9):1638–1641
  11. Adams PC, Reboussin DM, Press RD, et al. Biological variability of transferrin saturation and unsaturated iron-binding capacity. Am J Med. 2007;120(11):999;e1-e7
  12. Ford BA, Coyne DW, Eby CS, Scott MG. Variability of ferritin measurements in chronic kidney disease; implications for iron management. Kidney Int. 2009;75(1):104–110
  13. National Kidney Foundation. KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Anemia in Chronic Kidney Disease. Am J Kidney Dis. 2006;47(suppl 3):S11–S145
  14. Akizawa T, Pisoni RL, Akiba T, et al. Japanese haemodialysis anaemia management practices and outcomes (1999-2006): results from the DOPPS. Nephrol Dial Transplant. 2008;23(11):3643–3653
  15. Fraser CG. Biological variation data for setting quality specifications. http://www.westgard.com/site-map-2.htmAccessed June 2, 2010

 Originally published online as doi:10.1053/j.ajkd.2010.05.009 on July 20, 2010.

PII: S0272-6386(10)00918-2

doi: 10.1053/j.ajkd.2010.05.009

American Journal of Kidney Diseases
Volume 56, Issue 3 , Pages 540-546 , September 2010

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