American Journal of Kidney Diseases
Volume 56, Issue 4 , Pages 619-622 , October 2010

Filtration Markers in Acute Kidney Injury

  • Andrew S. Levey, MD

      Affiliations

    • Tufts Medical Center, Boston, Massachussetts
    • Corresponding Author InformationAddress correspondence to Andrew S. Levey, MD, Division of Nephrology, Tufts Medical Center Box 391, 800 Washington St, Boston, MA 02111
    • ,
  • Aneet Deo, MD, MS

      Affiliations

    • Tufts Medical Center, Boston, Massachussetts
    • ,
  • Bertrand L. Jaber, MD, MS

      Affiliations

    • St Elizabeth's Medical Center, Boston, Massachusetts

References 

  1. Coca SG, Yusuf B, Shlipak MG, Garg AX, Parikh CR. Long-term risk of mortality and other adverse outcomes after acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis. 2009;53(6):961–973
  2. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P. Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care. 2004;8(4):R204–R212
  3. Mehta RL, Kellum JA, Shah SV, et al. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007;11(2):R31
  4. Briguori C, Visconti G, Rivera NV, et al. Cystatin C and contrast-induced acute kidney injury. Circulation. 2010;121(19):2117–2122
  5. Coca SG, Yalavarthy R, Concato J, Parikh CR. Biomarkers for the diagnosis and risk stratification of acute kidney injury: a systematic review. Kidney Int. 2008;73(9):1008–1016
  6. Stevens LA, Levey AS. Measured GFR as a confirmatory test for estimated GFR. J Am Soc Nephrol. 2009;20(11):2305–2313
  7. Stevens LA, Schmid CH, Greene T, et al. Factors other than glomerular filtration rate affect serum cystatin C levels. Kidney Int. 2009;75(6):652–660
  8. Fricker M, Wiesli P, Brändle M, Schwegler B, Schmid C. Impact of thyroid dysfunction on serum cystatin C. Kidney Int. 2003;63(5):1944–1947
  9. Perianayagam MC, Seabra VF, Tighiouart H, Liangos O, Jaber BL. Serum cystatin C for prediction of dialysis requirement or death in acute kidney injury: a comparative study. Am J Kidney Dis. 2009;54(6):1025–1033
  10. Waikar SS, Bonventre JV. Creatinine kinetics and the definition of acute kidney injury. J Am Soc Nephrol. 2009;20(3):672–679
  11. Doi K, Yuen PS, Eisner C, et al. Reduced production of creatinine limits its use as marker of kidney injury in sepsis. J Am Soc Nephrol. 2009;20(6):1217–1221
  12. Sjöström P, Tidman M, Jones I. The shorter t1/2 of cystatin C explains the earlier change of its serum level compared to serum creatinine. Clin Nephrol. 2004;62(3):241–242
  13. Tenstad O, Roald AB, Grubb A, Aukland K. Renal handling of radiolabelled human cystatin C in the rat. Scand J of Clin Lab Invest. 1996;56(5):409–414
  14. Abu-Omar Y, Mussa S, Naik MJ, MacCarthy N, Standing S, Taggart DP. Evaluation of cystatin C as a marker of renal injury following on-pump and off-pump coronary surgery. Eur J Cardiothorac Surg. 2005;27(5):893–898
  15. Biancofiore G, Pucci L, Cerutti E, et al. Cystatin C as a marker of renal function immediately after liver transplantation. Liver Transpl. 2006;12(2):285–291
  16. Stabuc B, Vrhovec L, Stabuc-Silih M, Cizej TE. Improved prediction of decreased creatinine clearance by serum cystatin C: use in cancer patients before and during chemotherapy. Clin Chem. 2000;46(2):193–197
  17. Benöhr P, Grenz A, Hartmann JT, Müller GA, Blaschke S. Cystatin C--a marker for assessment of the glomerular filtration rate in patients with cisplatin chemotherapy. Kidney Blood Press Res. 2006;29(1):32–35
  18. Zhu J, Yin R, Wu H, et al. Cystatin C as a reliable marker of renal function following heart valve replacement surgery with cardiopulmonary bypass. Clin Chim Acta. 2006;374(1-2):116–121
  19. Villa P, Jiménez M, Soriano MC, Manzanares J, Casasnovas P. Serum cystatin C concentration as a marker of acute renal dysfunction in critically ill patients. Crit Care. 2005;9(2):R139–R143
  20. Herget-Rosenthal S, Marggraf G, Hüsing J, et al. Early detection of acute renal failure by serum cystatin C. Kidney Int. 2004;66(3):1115–1122
  21. Ahlström A, Tallgren M, Peltonen S, Pettilä V. Evolution and predictive power of serum cystatin C in acute renal failure. Clin Nephrol. 2004;62(5):344–350
  22. Koyner JL, Bennett MR, Worcester EM, et al. Urinary cystatin C as an early biomarker of acute kidney injury following adult cardiothoracic surgery. Kidney Int. 2008;74(8):1059–1069
  23. Wald R, Liangos O, Perianayagam MC, et al. Plasma cystatin C and acute kidney injury after cardiopulmonary bypass [published online ahead of print June 3, 2010]. Clin J Am Soc Nephrol. doi:10.2215/CJN.06350909.
  24. Haase-Fielitz A, Bellomo R, Devarajan P, et al. Novel and conventional serum biomarkers predicting acute kidney injury in adult cardiac surgery--a prospective cohort study. Crit Care Med. 2009;37(2):553–560
  25. Krawczeski CD, Vandevoorde RG, Kathman T, et al. Serum cystatin C is an early predictive biomarker of acute kidney injury after pediatric cardiopulmonary bypass [published online ahead of print June 10, 2010]. Clin J Am Soc Nephrol. doi:10.2215/CJN.02040310.
  26. Bell M, Granath F, Mårtensson J, Löfberg E, Ekbom A, Martling CR KING (Karolinska Intensive care Nephrology Group). Cystatin C is correlated with mortality in patients with and without acute kidney injury. Nephrol Dial Transplant. 2009;24(10):3096–3102
  27. Ristikankare A, Pöyhiä R, Kuitunen A, et al. Serum cystatin C in elderly cardiac surgery patients. Ann Thorac Surg. 2010;89(3):689–694
  28. White CA, Akbari A, Doucette S, et al. Effect of clinical variables and immunosuppression on serum cystatin C and beta-trace protein in kidney transplant recipients. Am J Kidney Dis. 2009;54(5):922–930
  29. Jelliffe R. Estimation of creatinine clearance in patients with unstable renal function, without a urine specimen. Am J Nephrol. 2002;22(4):320–324
  30. Kassirer JP. Clinical evaluation of kidney function--glomerular function. N Engl J Med. 1971;285(7):385–389

 Originally published online as doi:10.1053/j.ajkd.2010.08.001 on September 1, 2010.

PII: S0272-6386(10)01148-0

doi: 10.1053/j.ajkd.2010.08.001

American Journal of Kidney Diseases
Volume 56, Issue 4 , Pages 619-622 , October 2010

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