ATLAS OF RENAL PATHOLOGY

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Indinavir Nephropathy

Pathology Editor: Agnes Fogo, MD
Medical Photographer: Brent Weedman

 
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Fig 1. Indinavir may cause a tubulointerstitial nephritis. In this case, there is chronic tubulointerstitial nephritis with interstitial fibrosis and marked lymphoplasmacytic infiltrate. (Masson's trichrome, original magnification X100).
 
 
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Fig 2. Indinavir nephropathy is caused by intratubular precipitation of indinavir crystals with histiocytic reaction and sloughed degenerated tubular epithelial cells, as shown here. (Masson's trichrome, original magnification X400).
 

From the Department of Pathology, Vanderbilt University Medical Center, Nashville, TN.
Address author queries to Agnes Fogo, MD, Department of Pathology, Vanderbilt University Medical Center, MCN C-3310, Nashville, TN 37232. E-mail:Agnes.Fogo@vanderbilt.edu
Am J Kidney Dis 36(4):E22, 2000 (available www.ajkd.org)
 Copyright 2000 by the National Kidney Foundation, Inc.

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