Advertisement
American Journal of Kidney Diseases

Metastatic renal carcinoma in a pediatric recipient of an adult cadaveric donor kidney

      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      A 15-year old male with chronic renal failure secondary to obstructive uropathy received an adult cadaveric donor kidney. Evaluation for painless macroscopic hematuria occurring 2 years after transplantation disclosed a metastatic renal cell carcinoma, which by the use of restriction fragment length polymorphism analysis was shown to be of the donor's origin. Transplant nephrectomy and cessation of immunosuppressive therapy resulted in complete regression of multiple pulmonary metastases.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to American Journal of Kidney Diseases
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Penn I
        De novo malignancy in pediatric organ transplant recipients.
        J Pediatr Surg. 1994; 29: 221-228
        • Booth CM
        Renal parenchymal carcinoma in children.
        Br J Surg. 1986; 73: 313-317
        • Broeker B
        Renal cell carcinoma in children.
        Urology. 1991; 38: 54-56
        • Thoenes W
        • Stoerkel S
        • Rumpelt HJ
        Histopathology and classification of renal cell tumors (adenomas, oncocytomas and carcinomas).
        in: The basic cytological and histological elements and their use for diagnosis. ed 2. Pathol Res Pract. 181. 1986: 125-143
        • Mantiatis T
        • Fristch EF
        • Sambrook J
        Molecular Cloning: A Laboratory Manual.
        Cold Spring Harbor Laboratory, Cold Spring Harbor, NY1982
        • Lien YH
        • Kam I
        • Shanley PF
        • Schroter GP
        Metastatic renal cell carcinoma associated with acquired cystic kidney disease 15 years after successful renal transplantation.
        Am J Kidney Dis. 1991; 18: 711-715
        • Lien YH
        • Hunt KR
        • Siskind MS
        • Zukoski C
        Association of cyclosporin A with acquired cystic kidney disease of the native kidneys in renal transplant recipients.
        Kidney Int. 1993; 44: 613-616
        • Vogt P
        • Frei U
        • Repp H
        • Bunzegahl H
        • Oldhafer K
        • Pichlmayr R
        Malignant tumors in renal transplant recipients receiving cyclosporin.
        Nephrol Dial Transplant. 1990; 5: 282-288
        • Penn I
        Donor transmitted disease: Cancer.
        Transplant Proc. 1991; 23: 2629-2631
        • Dehner LP
        • Leestma JE
        • Price EB
        Renal cell carcinoma in children: A clinicopathologic study of 15 cases and a review of the literature.
        J Pediatr. 1970; 76: 358-368
        • Leuschner I
        • Harns D
        • Schmidt D
        Renal cell carcinoma in children: Histology, immunohistochemistry, and follow-up of 10 cases.
        Med Pediatr Oncol. 1991; 19: 33-41