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American Journal of Kidney Diseases

Idiopathic Granulomatous Interstitial Nephritis Responsive to Mycophenolate Mofetil Therapy

Published:December 05, 2013DOI:https://doi.org/10.1053/j.ajkd.2013.10.045
      Granulomatous interstitial nephritis (GIN) is a rare histologic disease. Various causes have been reported in the literature, including drugs, sarcoidosis, and infections. Other incidents have no discernible cause and are identified as idiopathic. We report a 68-year-old white man who presented with acute kidney injury and was given a diagnosis of idiopathic GIN. Mycophenolate mofetil treatment was elected because of steroid toxicity. He responded well to mycophenolate mofetil and has been in remission for more than 3 years. To our knowledge, this is the first report of successful treatment with mycophenolate mofetil of an adult patient with idiopathic GIN.

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