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American Journal of Kidney Diseases

Comparison of Patient Survival Between Hemodialysis and Peritoneal Dialysis Among Patients Eligible for Both Modalities

Published:November 22, 2017DOI:https://doi.org/10.1053/j.ajkd.2017.08.028

      Background

      Although peritoneal dialysis (PD) costs less to the health care system compared to in-center hemodialysis (HD), it is an underused therapy. Neither modality has been consistently shown to confer a clear benefit to patient survival. A key limitation of prior research is that study patients were not restricted to those eligible for both therapies.

      Study Design

      Retrospective cohort study.

      Setting & Participants

      All adult patients developing end-stage renal disease from January 2004 to December 2013 at any of 7 regional dialysis centers in Ontario, Canada, who had received at least 1 outpatient dialysis treatment and had completed a multidisciplinary modality assessment.

      Predictor

      HD or PD.

      Outcomes

      Mortality from any cause.

      Results

      Among all incident patients with end-stage renal disease (1,579 HD and 453 PD), PD was associated with lower risk for death among patients younger than 65 years. However, after excluding approximately one-third of all incident patients deemed to be ineligible for PD, the modalities were associated with similar survival regardless of age. This finding was also observed in analyses that were restricted to patients initiating dialysis therapy electively as outpatients. The impact of modality on survival did not vary over time.

      Limitations

      The determination of PD eligibility was based on the judgment of the multidisciplinary team at each dialysis center.

      Conclusions

      HD and PD are associated with similar mortality among incident dialysis patients who are eligible for both modalities. The effect of modality on survival does not appear to change over time. Future comparisons of dialysis modality should be restricted to individuals who are deemed eligible for both modalities to reflect the outcomes of patients who have the opportunity to choose between HD and PD in clinical practice.

      Index Words

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      Linked Article

      • Dialysis Modality Survival Comparison: Time to End the Debate, It’s a Tie
        American Journal of Kidney DiseasesVol. 71Issue 3
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          Chronic kidney disease remains a significant public health burden, with more than 678,000 prevalent patients with end-stage renal disease (ESRD) in the United States at the end of 2014.1 Regrettably, this number continues to increase by about 21,000 new cases every year, with only 2.6% receiving a preemptive kidney transplant.1 The vast majority of these incident patients with ESRD are initiated on hemodialysis (HD) therapy, with <10% on peritoneal dialysis (PD) therapy.1 During the past several decades, numerous studies have attempted to compare the risk for death between HD and PD, with conflicting results.
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