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Publication stageIn Press Journal Pre-Proof
Hematuria, which refers to the presence of blood in the urine, is has been reported to associate with increased risk of chronic kidney disease (CKD). However, the relationship between hematuria that persists over time and kidney function is not clear. In this large study consisting of relatively young and healthy Korean adults, we investigated the association between episodes of microscopic hematuria and the development of CKD. We found that microscopic hematuria, especially when persistent, was associated with worse kidney function. These associations were stronger in men compared with women but were readily apparent in both sex groups. Our study suggests that individuals with prolonged hematuria should be monitored, and that they may be candidates for early preventive strategies to decrease the risk of subsequent CKD.
Authors’ Contributions: Study conception and design: YJU, YC, SR; data acquisition: YJU, YC, M-JK, H-SJ, SR; data analysis: SR; data interpretation: YJU, YC, YK, M-JK, H-SJ, K-BL, KJJ, IYC, SHW, CDB, SR. Each author contributed important intellectual content during manuscript drafting or revision and agrees to be personally accountable for the individual’s own contributions and to ensure that questions pertaining to the accuracy or integrity of any portion of the work, even one in which the author was not directly involved, are appropriately investigated and resolved, including with documentation in the literature if appropriate.
Support: This study was supported by SKKU Excellence in Research Award Research Fund, Sungkyunkwan University, 2020. CDB is supported in part by the Southampton National Institute for Health Research Biomedical Research Centre (IS-BRC-20004), UK. However, the funders were not involved in defining the content of the manuscript.
Financial Disclosure: The authors declare that they have no relevant financial interests.
Peer Review: Received May 24, 2022. Evaluated by 2 external peer reviewers, with direct editorial input from a Statistics/Methods Editor, an International Editor, and the Editor-in-Chief. Accepted in revised form September 11, 2022.\