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Tip Lesion Variant of FSGS

Pathology Editor: Agnes Fogo, MD
Medical Photographer: Brent Weedman
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Fig 1. The localized sclerotic lesion that only involves the proximal tubular pole of the glomerulus has been classified as the tip lesion, with some evidence suggesting a better prognosis than typical FSGS. As in minimal change disease and FSGS, there are no immune complexes, and electron microscopy shows extensive foot process effacement (not shown, see minimal change disease). (Jones' silver stain, X200).
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Fig 2. The sclerotic lesion here is sharply localized to the proximal tubular pole, with adhesion and continuity of the capillary loop to Bowman's capsule, and intercapillary foam cells localized to this area, characteristic of the so-called tip lesion variant of FSGS. (Jones' silver stain, X400).

From the Department of Pathology, Vanderbilt University Medical Center, Nashville, TN.
Address author queries to Agnes Fogo, MD, Department of Pathology, Vanderbilt University Medical Center, MCN C-3310, Nashville, TN 37232. E-mail:[email protected]
Am J Kidney Dis 38(6):E30, 2001 (available
 Copyright 2001 by the National Kidney Foundation, Inc.

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